Abstract
THE effect of transient forebrain ischemia on NADPH- diaphorase-containing neurons was examined in the dentate gyrus of the gerbil. NADPH-diaphorase histochemistry was performed in animals subjected to temporary occlusion of the common carotid arteries and sham-operated animals. Seven days following transient ischemia, the number of NADPH-diaphorase-positive neurons in the infragranular zone of the dentate gyrus was reduced by approximately 50% compared with control animals. Since neighboring granule cells are known to be resistant to this level of ischemic challenge, the present observations indicate that NADPH-diaphorase-containing neurons in the dentate gyrus are selectively vulnerable to brief ischemia.
Original language | English (US) |
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Pages (from-to) | 84-86 |
Number of pages | 3 |
Journal | NeuroReport |
Volume | 5 |
Issue number | 1 |
DOIs | |
State | Published - Oct 1993 |
Keywords
- Dentate gyrus
- Ischemia
- Nitric oxide synthase
- Selective vulnerability
ASJC Scopus subject areas
- General Neuroscience