Selective loss of NADPH-diaphorase-containing neurons in the dentate gyrus following transient ischemia

Seung Chyul Hong, Giuseppe Lanzino, Jennifer Collins, Neal F. Kassell, Kevin S. Lee

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

THE effect of transient forebrain ischemia on NADPH- diaphorase-containing neurons was examined in the dentate gyrus of the gerbil. NADPH-diaphorase histochemistry was performed in animals subjected to temporary occlusion of the common carotid arteries and sham-operated animals. Seven days following transient ischemia, the number of NADPH-diaphorase-positive neurons in the infragranular zone of the dentate gyrus was reduced by approximately 50% compared with control animals. Since neighboring granule cells are known to be resistant to this level of ischemic challenge, the present observations indicate that NADPH-diaphorase-containing neurons in the dentate gyrus are selectively vulnerable to brief ischemia.

Original languageEnglish (US)
Pages (from-to)84-86
Number of pages3
JournalNeuroReport
Volume5
Issue number1
DOIs
StatePublished - Oct 1993

Keywords

  • Dentate gyrus
  • Ischemia
  • Nitric oxide synthase
  • Selective vulnerability

ASJC Scopus subject areas

  • Neuroscience(all)

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