Selective loss of NADPH-diaphorase-containing neurons in the dentate gyrus following transient ischemia

Seung Chyul Hong, Giuseppe Lanzino, Jennifer Collins, Neal F. Kassell, Kevin S. Lee

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

THE effect of transient forebrain ischemia on NADPH- diaphorase-containing neurons was examined in the dentate gyrus of the gerbil. NADPH-diaphorase histochemistry was performed in animals subjected to temporary occlusion of the common carotid arteries and sham-operated animals. Seven days following transient ischemia, the number of NADPH-diaphorase-positive neurons in the infragranular zone of the dentate gyrus was reduced by approximately 50% compared with control animals. Since neighboring granule cells are known to be resistant to this level of ischemic challenge, the present observations indicate that NADPH-diaphorase-containing neurons in the dentate gyrus are selectively vulnerable to brief ischemia.

Original languageEnglish (US)
Pages (from-to)84-86
Number of pages3
JournalNeuroReport
Volume5
Issue number1
StatePublished - 1993
Externally publishedYes

Fingerprint

NADPH Dehydrogenase
Dentate Gyrus
Ischemia
Neurons
Gerbillinae
Common Carotid Artery
Prosencephalon

Keywords

  • Dentate gyrus
  • Ischemia
  • Nitric oxide synthase
  • Selective vulnerability

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Hong, S. C., Lanzino, G., Collins, J., Kassell, N. F., & Lee, K. S. (1993). Selective loss of NADPH-diaphorase-containing neurons in the dentate gyrus following transient ischemia. NeuroReport, 5(1), 84-86.

Selective loss of NADPH-diaphorase-containing neurons in the dentate gyrus following transient ischemia. / Hong, Seung Chyul; Lanzino, Giuseppe; Collins, Jennifer; Kassell, Neal F.; Lee, Kevin S.

In: NeuroReport, Vol. 5, No. 1, 1993, p. 84-86.

Research output: Contribution to journalArticle

Hong, SC, Lanzino, G, Collins, J, Kassell, NF & Lee, KS 1993, 'Selective loss of NADPH-diaphorase-containing neurons in the dentate gyrus following transient ischemia', NeuroReport, vol. 5, no. 1, pp. 84-86.
Hong, Seung Chyul ; Lanzino, Giuseppe ; Collins, Jennifer ; Kassell, Neal F. ; Lee, Kevin S. / Selective loss of NADPH-diaphorase-containing neurons in the dentate gyrus following transient ischemia. In: NeuroReport. 1993 ; Vol. 5, No. 1. pp. 84-86.
@article{d87d76c0681b422cb57ef85c80704d67,
title = "Selective loss of NADPH-diaphorase-containing neurons in the dentate gyrus following transient ischemia",
abstract = "THE effect of transient forebrain ischemia on NADPH- diaphorase-containing neurons was examined in the dentate gyrus of the gerbil. NADPH-diaphorase histochemistry was performed in animals subjected to temporary occlusion of the common carotid arteries and sham-operated animals. Seven days following transient ischemia, the number of NADPH-diaphorase-positive neurons in the infragranular zone of the dentate gyrus was reduced by approximately 50{\%} compared with control animals. Since neighboring granule cells are known to be resistant to this level of ischemic challenge, the present observations indicate that NADPH-diaphorase-containing neurons in the dentate gyrus are selectively vulnerable to brief ischemia.",
keywords = "Dentate gyrus, Ischemia, Nitric oxide synthase, Selective vulnerability",
author = "Hong, {Seung Chyul} and Giuseppe Lanzino and Jennifer Collins and Kassell, {Neal F.} and Lee, {Kevin S.}",
year = "1993",
language = "English (US)",
volume = "5",
pages = "84--86",
journal = "NeuroReport",
issn = "0959-4965",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Selective loss of NADPH-diaphorase-containing neurons in the dentate gyrus following transient ischemia

AU - Hong, Seung Chyul

AU - Lanzino, Giuseppe

AU - Collins, Jennifer

AU - Kassell, Neal F.

AU - Lee, Kevin S.

PY - 1993

Y1 - 1993

N2 - THE effect of transient forebrain ischemia on NADPH- diaphorase-containing neurons was examined in the dentate gyrus of the gerbil. NADPH-diaphorase histochemistry was performed in animals subjected to temporary occlusion of the common carotid arteries and sham-operated animals. Seven days following transient ischemia, the number of NADPH-diaphorase-positive neurons in the infragranular zone of the dentate gyrus was reduced by approximately 50% compared with control animals. Since neighboring granule cells are known to be resistant to this level of ischemic challenge, the present observations indicate that NADPH-diaphorase-containing neurons in the dentate gyrus are selectively vulnerable to brief ischemia.

AB - THE effect of transient forebrain ischemia on NADPH- diaphorase-containing neurons was examined in the dentate gyrus of the gerbil. NADPH-diaphorase histochemistry was performed in animals subjected to temporary occlusion of the common carotid arteries and sham-operated animals. Seven days following transient ischemia, the number of NADPH-diaphorase-positive neurons in the infragranular zone of the dentate gyrus was reduced by approximately 50% compared with control animals. Since neighboring granule cells are known to be resistant to this level of ischemic challenge, the present observations indicate that NADPH-diaphorase-containing neurons in the dentate gyrus are selectively vulnerable to brief ischemia.

KW - Dentate gyrus

KW - Ischemia

KW - Nitric oxide synthase

KW - Selective vulnerability

UR - http://www.scopus.com/inward/record.url?scp=0027427717&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027427717&partnerID=8YFLogxK

M3 - Article

C2 - 7506592

AN - SCOPUS:0027427717

VL - 5

SP - 84

EP - 86

JO - NeuroReport

JF - NeuroReport

SN - 0959-4965

IS - 1

ER -