Selective inhibitors of MEK1/ERK ^44/42 and p38 mitogen-activated protein kinases potentiate apoptosis induction by sulindac sulfide in human colon carcinoma cells

Medicine & Life Sciences

• sulindac sulfide 100%
• p38 Mitogen-Activated Protein Kinases 59%
• Cyclooxygenase 2 50%
• Colon 46%
• Carcinoma 38%
• Apoptosis 35%
• Mitogen-Activated Protein Kinases 28%
• Anti-Inflammatory Agents 21%
• Mitogen-Activated Protein Kinase Kinases 20%
• Colonic Neoplasms 17%
• Sulindac 14%
• N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 13%
• Pharmaceutical Preparations 11%
• SB 203580 11%
• 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 11%
• Cyclooxygenase 2 Inhibitors 11%
• Antisense Oligonucleotides 11%
• Prostaglandin-Endoperoxide Synthases 10%
• Protein Kinase Inhibitors 10%
• Polyps 9%
• Cultured Cells 8%
• Colorectal Neoplasms 7%
• Signal Transduction 7%
• Cell Death 7%
• Cell Line 5%
• Growth 4%
• Proteins 3%