Selective Inhibition of BFL1: It's All about Finding the Right Partner

Haiming Dai, X. Wei Meng, Scott H. Kaufmann

Research output: Contribution to journalArticle

Abstract

In this issue of Cell Chemical Biology, Harvey et al. (2020) identify 4E14, a sulfhydryl-containing N-acetyltryptophan analog that selectively disrupts binding to the previously undruggable anti-apoptotic BCL2 paralog BFL1, and elucidate a BFL1 conformational change that facilitates 4E14 interaction. These results provide insight that will accelerate development of BFL1 inhibitors.

Original languageEnglish (US)
Pages (from-to)639-642
Number of pages4
JournalCell Chemical Biology
Volume27
Issue number6
DOIs
StatePublished - Jun 18 2020

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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