Abstract
In this issue of Cell Chemical Biology, Harvey et al. (2020) identify 4E14, a sulfhydryl-containing N-acetyltryptophan analog that selectively disrupts binding to the previously undruggable anti-apoptotic BCL2 paralog BFL1, and elucidate a BFL1 conformational change that facilitates 4E14 interaction. These results provide insight that will accelerate development of BFL1 inhibitors.
Original language | English (US) |
---|---|
Pages (from-to) | 639-642 |
Number of pages | 4 |
Journal | Cell Chemical Biology |
Volume | 27 |
Issue number | 6 |
DOIs |
|
State | Published - Jun 18 2020 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmacology
- Drug Discovery
- Clinical Biochemistry