Selective Inhibition of BFL1: It's All about Finding the Right Partner

Haiming Dai; X. Wei Meng; Scott H. Kaufmann

doi:10.1016/j.chembiol.2020.05.014

Selective Inhibition of BFL1: It's All about Finding the Right Partner

Haiming Dai, X. Wei Meng, Scott H. Kaufmann

Oncology

Research output: Contribution to journal › Article

Abstract

In this issue of Cell Chemical Biology, Harvey et al. (2020) identify 4E14, a sulfhydryl-containing N-acetyltryptophan analog that selectively disrupts binding to the previously undruggable anti-apoptotic BCL2 paralog BFL1, and elucidate a BFL1 conformational change that facilitates 4E14 interaction. These results provide insight that will accelerate development of BFL1 inhibitors.

Original language	English (US)
Pages (from-to)	639-642
Number of pages	4
Journal	Cell Chemical Biology
Volume	27
Issue number	6
DOIs	https://doi.org/10.1016/j.chembiol.2020.05.014
State	Published - Jun 18 2020

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmacology
Drug Discovery
Clinical Biochemistry

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Dai, H., Meng, X. W., & Kaufmann, S. H. (2020). Selective Inhibition of BFL1: It's All about Finding the Right Partner. Cell Chemical Biology, 27(6), 639-642. https://doi.org/10.1016/j.chembiol.2020.05.014

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