Abstract
Chromosomal translocations or DNA rearrangements affecting c-myc occur in almost all murine plasmacytoma and human Burkitt's lymphoma tumors and are associated with a high incidence of exon 2 missense mutations and selective expression of the affected allele. Screening nine multiple myeloma cell lines, we identified no exon 2 missense mutations but did identify two lines with single, silent mutations in exon 1 and exon 2, respectively. Each of these informative multiple myeloma cell lines selectively expresses only one c-myc allele despite the apparent absence of chromosomal translocations or DNA rearrangements affecting c-myc.
Original language | English (US) |
---|---|
Pages (from-to) | 4370-4373 |
Number of pages | 4 |
Journal | Cancer research |
Volume | 56 |
Issue number | 19 |
State | Published - Oct 1 1996 |
ASJC Scopus subject areas
- Oncology
- Cancer Research