Selective expression of one c-myc allele in two human myeloma cell lines

W. Michael Kuehl, Leslie A. Brents, Marta Chesi, P. Leif Bergsagel

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Chromosomal translocations or DNA rearrangements affecting c-myc occur in almost all murine plasmacytoma and human Burkitt's lymphoma tumors and are associated with a high incidence of exon 2 missense mutations and selective expression of the affected allele. Screening nine multiple myeloma cell lines, we identified no exon 2 missense mutations but did identify two lines with single, silent mutations in exon 1 and exon 2, respectively. Each of these informative multiple myeloma cell lines selectively expresses only one c-myc allele despite the apparent absence of chromosomal translocations or DNA rearrangements affecting c-myc.

Original languageEnglish (US)
Pages (from-to)4370-4373
Number of pages4
JournalCancer research
Volume56
Issue number19
StatePublished - Oct 1 1996

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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