Selective effects of serotonergic psychoactive agents on gastrointestinal functions in health

Heather J. Chial, Michael Camilleri, Duane Burton, George Thomforde, Kevin W. Olden, Debra Stephens

Research output: Contribution to journalArticle

109 Scopus citations

Abstract

This study evaluated the effects of serotonergic psychoactive agents on gastrointestinal functions in healthy human subjects. Participants received one of four regimens in a randomized, double-blind manner: buspirone, a 5-HT1A receptor agonist (10 mg twice daily); paroxetine, a selective serotonin reuptake inhibitor (20 mg daily); venlafaxine-XR, a selective serotonin and norepinephrine reuptake inhibitor (75 mg daily); or placebo for 11 days. Physiological testing performed on days 8-11 included scintigraphic assessment of gastrointestinal and colonic transit, the nutrient drink test, and assessment of the postprandial change in gastric volume. Fifty-one healthy adults (40 females, 11 males) participated in this study. No effects on gastric emptying or colonic transit were identified with any agent. Small bowel transit of a solid meal was accelerated by paroxetine. Buspirone decreased postprandial aggregate symptom and nausea scores. Venlafaxine-XR increased the postprandial change in gastric volume. Buspirone, paroxetine, and venlafaxine-XR affect upper gastrointestinal functions in healthy humans. These data support the need for clinical and physiological studies of these agents in functional gastrointestinal disorders.

Original languageEnglish (US)
Pages (from-to)G130-G137
JournalAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
Volume284
Issue number1 47-1
DOIs
StatePublished - Jan 1 2003

Keywords

  • Antidepressant
  • Buspirone
  • Motility
  • Paroxetine
  • Venlafaxine

ASJC Scopus subject areas

  • Physiology
  • Hepatology
  • Gastroenterology
  • Physiology (medical)

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