TY - JOUR
T1 - Selective destruction of preganglionic sympathetic nerves by antibodies to acetylcholinesterase
AU - Brimijoin, S.
AU - Lennon, V. A.
PY - 1991
Y1 - 1991
N2 - Systemic injection of monoclonal antibodies to neural acetyl cholinesterase in rats causes permanent, complement-mediated destruction of presynaptic fibers in sympathetic ganglia and adrenal medulla. Ptosis, hypotension, bradycardia, and postural syncope ensue. In sympathetic ganglia, cholinergic synapses disappear, but postganglionic adrenergic neurones remain structurally and functionally normal. Somatic motor and parasympathetic systems are also spared. This model of selective cholinergic autoimmunity is a new tool for autonomic physiology and may be relevant to the pathogenesis of human dysautonomias.
AB - Systemic injection of monoclonal antibodies to neural acetyl cholinesterase in rats causes permanent, complement-mediated destruction of presynaptic fibers in sympathetic ganglia and adrenal medulla. Ptosis, hypotension, bradycardia, and postural syncope ensue. In sympathetic ganglia, cholinergic synapses disappear, but postganglionic adrenergic neurones remain structurally and functionally normal. Somatic motor and parasympathetic systems are also spared. This model of selective cholinergic autoimmunity is a new tool for autonomic physiology and may be relevant to the pathogenesis of human dysautonomias.
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U2 - 10.1007/978-3-7091-9175-0_18
DO - 10.1007/978-3-7091-9175-0_18
M3 - Article
C2 - 1817157
AN - SCOPUS:0026357967
SN - 0303-6995
SP - 139
EP - 145
JO - Journal of Neural Transmission, Supplement
JF - Journal of Neural Transmission, Supplement
IS - 34
ER -