Selective destruction of preganglionic sympathetic nerves by antibodies to acetylcholinesterase

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11 Scopus citations

Abstract

Systemic injection of monoclonal antibodies to neural acetyl cholinesterase in rats causes permanent, complement-mediated destruction of presynaptic fibers in sympathetic ganglia and adrenal medulla. Ptosis, hypotension, bradycardia, and postural syncope ensue. In sympathetic ganglia, cholinergic synapses disappear, but postganglionic adrenergic neurones remain structurally and functionally normal. Somatic motor and parasympathetic systems are also spared. This model of selective cholinergic autoimmunity is a new tool for autonomic physiology and may be relevant to the pathogenesis of human dysautonomias.

Original languageEnglish (US)
Pages (from-to)139-145
Number of pages7
JournalJournal of Neural Transmission, Supplement
Issue number34
StatePublished - Dec 1 1991

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry

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