Selective convective brain cooling during normothermic cardiopulmonary bypass in dogs

C. T. Wass, J. R. Waggoner, D. G. Cable, Hartzell V Schaff, D. R. Schroeder, W. L. Lanier

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Objective: Although normothermic cardiopulmonary bypass results in improved cardiac outcome, patients do not benefit from hypothermic-mediated brain protection and thus may be at high risk for ischemic brain injury. The present study evaluated the efficacy of selective forced-air cerebral cooling. Methods: Sixteen dogs were anesthetized with either intravenous pentobarbital or inhaled halothane (n = 8 for each group). Temperatures were monitored in the esophagus (i.e., core), parietal epidural space, and brain parenchyma. Normothermic atrial-femoral cardiopulmonary bypass and forced- air pericranial cooling (to approximately 13°C) were maintained for 150 minutes. Data between groups were compared by means of repeated-measures analysis of variance and two-sample t test. Within each group, brain-to-core temperature gradients were compared to zero by means of the one-sample t test. Results: In pentobarbital-anesthetized dogs, after 30 minutes of cerebral cooling, temperatures in the parietal epidural space and 1 cm and 2 cm beneath the dura were 3.3°± 1.4°C (mean ± standard deviation), 2.6°± 13°C, and 1.1 ± ± 0.6°C cooler than the core temperature, respectively. At the conclusion of the study (i.e., 150 minutes), these temperatures were 4.5°± 1.8°C, 3.9°± 1.6°C, and 2.0°± 0.9°C cooler than the core temperature, respectively. Similar changes were observed in halothane-anesthetized dogs. Conclusions: Regardless of the background anesthetic, the magnitude of selective cerebral cooling observed in our study was larger than the 1°to 2°Γ changes previously reported to modulate ischemic brain injury.

Original languageEnglish (US)
Pages (from-to)1350-1357
Number of pages8
JournalJournal of Thoracic and Cardiovascular Surgery
Volume115
Issue number6
DOIs
StatePublished - 1998

Fingerprint

Cardiopulmonary Bypass
Dogs
Temperature
Brain
Epidural Space
Halothane
Pentobarbital
Brain Injuries
Air
Thigh
Esophagus
Anesthetics
Analysis of Variance

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Selective convective brain cooling during normothermic cardiopulmonary bypass in dogs. / Wass, C. T.; Waggoner, J. R.; Cable, D. G.; Schaff, Hartzell V; Schroeder, D. R.; Lanier, W. L.

In: Journal of Thoracic and Cardiovascular Surgery, Vol. 115, No. 6, 1998, p. 1350-1357.

Research output: Contribution to journalArticle

Wass, C. T. ; Waggoner, J. R. ; Cable, D. G. ; Schaff, Hartzell V ; Schroeder, D. R. ; Lanier, W. L. / Selective convective brain cooling during normothermic cardiopulmonary bypass in dogs. In: Journal of Thoracic and Cardiovascular Surgery. 1998 ; Vol. 115, No. 6. pp. 1350-1357.
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AB - Objective: Although normothermic cardiopulmonary bypass results in improved cardiac outcome, patients do not benefit from hypothermic-mediated brain protection and thus may be at high risk for ischemic brain injury. The present study evaluated the efficacy of selective forced-air cerebral cooling. Methods: Sixteen dogs were anesthetized with either intravenous pentobarbital or inhaled halothane (n = 8 for each group). Temperatures were monitored in the esophagus (i.e., core), parietal epidural space, and brain parenchyma. Normothermic atrial-femoral cardiopulmonary bypass and forced- air pericranial cooling (to approximately 13°C) were maintained for 150 minutes. Data between groups were compared by means of repeated-measures analysis of variance and two-sample t test. Within each group, brain-to-core temperature gradients were compared to zero by means of the one-sample t test. Results: In pentobarbital-anesthetized dogs, after 30 minutes of cerebral cooling, temperatures in the parietal epidural space and 1 cm and 2 cm beneath the dura were 3.3°± 1.4°C (mean ± standard deviation), 2.6°± 13°C, and 1.1 ± ± 0.6°C cooler than the core temperature, respectively. At the conclusion of the study (i.e., 150 minutes), these temperatures were 4.5°± 1.8°C, 3.9°± 1.6°C, and 2.0°± 0.9°C cooler than the core temperature, respectively. Similar changes were observed in halothane-anesthetized dogs. Conclusions: Regardless of the background anesthetic, the magnitude of selective cerebral cooling observed in our study was larger than the 1°to 2°Γ changes previously reported to modulate ischemic brain injury.

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