Selective arterial calcium stimulation with hepatic venous sampling differentiates insulinoma from nesidioblastosis

Scott M. Thompson, Adrian Vella, Geoffrey B. Thompson, Kandelaria M. Rumilla, F. John Service, Clive S. Grant, James C. Andrews

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Context: In adult patients with endogenous hyperinsulinemic hypoglycemia and negative or inconclusive noninvasive imaging, insulinoma and non-insulinoma pancreatogenous hypoglycemic syndrome (NIPHS) resulting from diffuse nesidioblastosis must be considered in the differential diagnosis. It is not known whether the biochemical results of selective arterial calcium stimulation (SACST) with hepatic venous sampling can differentiate insulinoma from diffuse nesidioblastosis. Objective: To determine the specificity of SACST with hepatic venous sampling in differentiating insulinoma from diffuse nesidioblastosis. Design: Retrospective review (January 1996 to March 2014). Setting: Tertiary referral center. Patients or Other Participants: A total of 116 patients with biochemical evidence of endogenous hyperinsulinemic hypoglycemia and negative or inconclusive noninvasive imaging who were subsequently shown at surgery to have insulinoma (n = 42) or nesidioblastosis (n = 74) after undergoing SACST with hepatic venous sampling. Intervention(s): SACST with hepatic venous sampling before pancreatic exploration. Main Outcome Measure(s): Receiver operating characteristic curves were generated from the biochemical results of SACST to determine the specificity of the maximum hepatic venous insulin concentration (mHVI) and the relative-fold increase in hepatic venous insulin concentration (rHVI) over baseline after calcium injection from the dominant artery in differentiating insulinoma from nesidioblastosis. Results: The mHVI (21.5-fold; P 91.5 and > 263.5μIU/mL were 95and100%specific for insulinoma, respectively.A19-fold increase in rHVI over baseline was 99% specific for insulinoma. Conclusions: These data suggest that the mHVI and rHVI at SACST may be useful in differentiating insulinoma from nesidioblastosis with high specificity in patients with hyperinsulinemic hypoglycemia and negative or inconclusive noninvasive imaging.

Original languageEnglish (US)
Pages (from-to)4189-4197
Number of pages9
JournalJournal of Clinical Endocrinology and Metabolism
Volume100
Issue number11
DOIs
StatePublished - Nov 1 2015

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism

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