Select dietary fatty acids attenuate cardiopulmonary dysfunction during acute lung injury in pigs

M. J. Murray, M. Kumar, T. J. Gregory, P. L. Banks, H. D. Tazelaar, S. J. DeMichele

Research output: Contribution to journalArticle

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Abstract

We examined the effect of substituting linoleic acid (LA) with eicosapentaenoic acid (EPA) and γ-linolenic acid (γ-LA), precursors of trienoic and monoenoic eicosanoids, respectively, on acute lung injury (ALI). Three groups (n = 8/group) of pigs were fed enteral diets containing LA (diet A), EPA (diet B), or EPA + γ-LA (diet C) for 8 days. ALI was then induced with a 0.1 mg/kg bolus of Escherichia coli endotoxin followed by a continuous infusion for 4 h (0.075 mg · kg-1 · h-1). Pulmonary arterial and capillary wedge pressures, cardiac index (CI), arterial blood gases, arterial O2 content, and plasma thromboxane B2 (TxB2) were measured. Arterial PO2 decreased at 20 min in animals fed diet A. This change was attenuated with diets B and C. The EPA- and EPA + γ-LA-enriched diets attenuated the fall in O2 delivery at 20 min, an improvement that was sustained throughout the 4-h study period with the EPA + γ-LA-enriched diet only. This improvement in O2 delivery was due not only to the improved arterial PO2, but also to the maintenance of CI at 20 min in animals fed diets B and C and throughout the 4-h study period in animals fed diet C. At 4 h, TxB2 increased 10-fold over baseline in animals fed diet A, whereas in animals fed diets B and C the increase was only 3-fold. These decreased TxB2 levels in animals fed diets B and C correlate with an attenuation in the increase in pulmonary vascular resistance that was observed at 20 min after endotoxin infusion in animals fed diet A. These data suggest that specialized enteral diets enriched in EPA + γ-LA improve gas exchange and O2 delivery, presumably in part through a modification of TxB2 production with a decrease in pulmonary vascular resistance and an increase in CI, during ALI.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume269
Issue number6 38-6
StatePublished - 1995

Fingerprint

Acute Lung Injury
Swine
Fatty Acids
Diet
Eicosapentaenoic Acid
Linoleic Acid
Thromboxane B2
Vascular Resistance
Small Intestine
Gases
Pulmonary Wedge Pressure
alpha-Linolenic Acid
Eicosanoids
Endotoxins

Keywords

  • adult respiratory distress syndrome
  • borage oil
  • eicosanoids
  • endotoxin
  • fish oil
  • nutrition
  • porcine model of acute respiratory distress syndrome
  • sepsis
  • shock
  • Sus scrofa

ASJC Scopus subject areas

  • Physiology

Cite this

Murray, M. J., Kumar, M., Gregory, T. J., Banks, P. L., Tazelaar, H. D., & DeMichele, S. J. (1995). Select dietary fatty acids attenuate cardiopulmonary dysfunction during acute lung injury in pigs. American Journal of Physiology - Heart and Circulatory Physiology, 269(6 38-6).

Select dietary fatty acids attenuate cardiopulmonary dysfunction during acute lung injury in pigs. / Murray, M. J.; Kumar, M.; Gregory, T. J.; Banks, P. L.; Tazelaar, H. D.; DeMichele, S. J.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 269, No. 6 38-6, 1995.

Research output: Contribution to journalArticle

Murray, MJ, Kumar, M, Gregory, TJ, Banks, PL, Tazelaar, HD & DeMichele, SJ 1995, 'Select dietary fatty acids attenuate cardiopulmonary dysfunction during acute lung injury in pigs', American Journal of Physiology - Heart and Circulatory Physiology, vol. 269, no. 6 38-6.
Murray, M. J. ; Kumar, M. ; Gregory, T. J. ; Banks, P. L. ; Tazelaar, H. D. ; DeMichele, S. J. / Select dietary fatty acids attenuate cardiopulmonary dysfunction during acute lung injury in pigs. In: American Journal of Physiology - Heart and Circulatory Physiology. 1995 ; Vol. 269, No. 6 38-6.
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