Seizures are a nonspecific neurological manifestation of cerebral dysfunction and not indicative of any particular disease processes or pathology. As such, the evaluation and treatment of seizures in transplant patients generally follow the same clinical approach as for other patients. A seizure in a transplant patient is commonly unanticipated and entirely unexplained. The effects can be substantial with aspiration, loss of vascular catheters, and tissue trauma. Patients undergoing organ transplantation are at risk of seizures for multiple reasons, and while much of the neurological and transplantation literature reports on the incidence of seizures according to the particular organ transplanted, there are many similarities (e.g., Immunosuppression drugs) and we will try to concentrate on organ transplantation as a whole.