Segregation analysis of idiopathic talipes equinovarus in a Texan population

Mariza De Andrade; Jill S. Barnholtz; Christopher I. Amos; Carollynn Lochmiller; Allison Scott; Marjorie Risman; Jacqueline T. Hecht

doi:10.1002/(SICI)1096-8628(19980901)79:2<97::AID-AJMG4>3.0.CO;2-K

Segregation analysis of idiopathic talipes equinovarus in a Texan population

Mariza De Andrade, Jill S. Barnholtz, Christopher I. Amos, Carollynn Lochmiller, Allison Scott, Marjorie Risman, Jacqueline T. Hecht

Health Sciences Research

Research output: Contribution to journal › Article

41 Scopus citations

Abstract

'Idiopathic' talipes equinovarus (ITEV) is a nonsyndromal congenital anomaly of one or both feet. Casting and surgery are often necessary to obtain correct foot alignment. In spite of treatment, residual deformities of the feet occur and calf muscles may be hypoplastic. The cause of ITEV is unknown but genetic factors have been postulated. Complex segregation analysis was performed on 173 ITEV families including 93 Caucasian and 48 Hispanic families. The recessive mixed model was the best fitting model and no differences were found based on ethnicity. These results confirm previous studies suggesting that there is a genetic component to the development of ITEV.

Original language	English (US)
Pages (from-to)	97-102
Number of pages	6
Journal	American journal of medical genetics
Volume	79
Issue number	2
DOIs	https://doi.org/10.1002/(SICI)1096-8628(19980901)79:2<97::AID-AJMG4>3.0.CO;2-K
State	Published - Sep 1 1998

Keywords

Birth defect
Clubfoot
Complex segregation analysis
ITEV
Idiopathic talipes equinovarus

ASJC Scopus subject areas

Genetics
Genetics(clinical)

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10.1002/(SICI)1096-8628(19980901)79:2<97::AID-AJMG4>3.0.CO;2-K

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De Andrade, M., Barnholtz, J. S., Amos, C. I., Lochmiller, C., Scott, A., Risman, M., & Hecht, J. T. (1998). Segregation analysis of idiopathic talipes equinovarus in a Texan population. American journal of medical genetics, 79(2), 97-102. https://doi.org/10.1002/(SICI)1096-8628(19980901)79:2<97::AID-AJMG4>3.0.CO;2-K

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abstract = "'Idiopathic' talipes equinovarus (ITEV) is a nonsyndromal congenital anomaly of one or both feet. Casting and surgery are often necessary to obtain correct foot alignment. In spite of treatment, residual deformities of the feet occur and calf muscles may be hypoplastic. The cause of ITEV is unknown but genetic factors have been postulated. Complex segregation analysis was performed on 173 ITEV families including 93 Caucasian and 48 Hispanic families. The recessive mixed model was the best fitting model and no differences were found based on ethnicity. These results confirm previous studies suggesting that there is a genetic component to the development of ITEV.",

keywords = "Birth defect, Clubfoot, Complex segregation analysis, ITEV, Idiopathic talipes equinovarus",

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AU - Barnholtz, Jill S.

AU - Amos, Christopher I.

AU - Lochmiller, Carollynn

AU - Scott, Allison

AU - Risman, Marjorie

AU - Hecht, Jacqueline T.

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