TY - JOUR
T1 - Segregation analysis of idiopathic talipes equinovarus in a Texan population
AU - De Andrade, Mariza
AU - Barnholtz, Jill S.
AU - Amos, Christopher I.
AU - Lochmiller, Carollynn
AU - Scott, Allison
AU - Risman, Marjorie
AU - Hecht, Jacqueline T.
PY - 1998/9/1
Y1 - 1998/9/1
N2 - 'Idiopathic' talipes equinovarus (ITEV) is a nonsyndromal congenital anomaly of one or both feet. Casting and surgery are often necessary to obtain correct foot alignment. In spite of treatment, residual deformities of the feet occur and calf muscles may be hypoplastic. The cause of ITEV is unknown but genetic factors have been postulated. Complex segregation analysis was performed on 173 ITEV families including 93 Caucasian and 48 Hispanic families. The recessive mixed model was the best fitting model and no differences were found based on ethnicity. These results confirm previous studies suggesting that there is a genetic component to the development of ITEV.
AB - 'Idiopathic' talipes equinovarus (ITEV) is a nonsyndromal congenital anomaly of one or both feet. Casting and surgery are often necessary to obtain correct foot alignment. In spite of treatment, residual deformities of the feet occur and calf muscles may be hypoplastic. The cause of ITEV is unknown but genetic factors have been postulated. Complex segregation analysis was performed on 173 ITEV families including 93 Caucasian and 48 Hispanic families. The recessive mixed model was the best fitting model and no differences were found based on ethnicity. These results confirm previous studies suggesting that there is a genetic component to the development of ITEV.
KW - Birth defect
KW - Clubfoot
KW - Complex segregation analysis
KW - ITEV
KW - Idiopathic talipes equinovarus
UR - http://www.scopus.com/inward/record.url?scp=0032168851&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032168851&partnerID=8YFLogxK
U2 - 10.1002/(SICI)1096-8628(19980901)79:2<97::AID-AJMG4>3.0.CO;2-K
DO - 10.1002/(SICI)1096-8628(19980901)79:2<97::AID-AJMG4>3.0.CO;2-K
M3 - Article
C2 - 9741466
AN - SCOPUS:0032168851
VL - 79
SP - 97
EP - 102
JO - American Journal of Medical Genetics, Part A
JF - American Journal of Medical Genetics, Part A
SN - 0148-7299
IS - 2
ER -