Segmental arterial mediolysis and fibromuscular dysplasia: What comes first, the chicken or the egg?

E. Tyler Hall; Blake A. Gibson; Charles T. Hennemeyer; Paola Devis; Stacey Black; Brandon T. Larsen

doi:10.1016/j.carpath.2015.11.004

Segmental arterial mediolysis and fibromuscular dysplasia: What comes first, the chicken or the egg?

E. Tyler Hall, Blake A. Gibson, Charles T. Hennemeyer, Paola Devis, Stacey Black, Brandon T. Larsen

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Segmental arterial mediolysis (SAM) is a rare vasculopathy characterized by lysis of the outer media in splanchnic arteries and formation of dissecting pseudoaneurysms that may spontaneously rupture, leading to massive and often fatal intraabdominal hemorrhage. The pathogenesis of SAM is poorly understood. Healed SAM lesions closely resemble fibromuscular dysplasia (FMD), leading some authors to postulate that SAM represents a precursor to FMD despite distinct clinical differences between these two disorders. Herein, we present a 61-year-old woman with fatal SAM who showed histologic features in her aorta suggesting the opposite pathogenetic relationship, with an unclassified "FMD-like" arteriopathy preceding development of SAM.

Original language	English (US)
Pages (from-to)	113-115
Number of pages	3
Journal	Cardiovascular Pathology
Volume	25
Issue number	2
DOIs	https://doi.org/10.1016/j.carpath.2015.11.004
State	Published - Mar 1 2016

Keywords

Fibromuscular dysplasia
Segmental arterial mediolysis

ASJC Scopus subject areas

Pathology and Forensic Medicine
Cardiology and Cardiovascular Medicine

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10.1016/j.carpath.2015.11.004

Cite this

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title = "Segmental arterial mediolysis and fibromuscular dysplasia: What comes first, the chicken or the egg?",

abstract = "Segmental arterial mediolysis (SAM) is a rare vasculopathy characterized by lysis of the outer media in splanchnic arteries and formation of dissecting pseudoaneurysms that may spontaneously rupture, leading to massive and often fatal intraabdominal hemorrhage. The pathogenesis of SAM is poorly understood. Healed SAM lesions closely resemble fibromuscular dysplasia (FMD), leading some authors to postulate that SAM represents a precursor to FMD despite distinct clinical differences between these two disorders. Herein, we present a 61-year-old woman with fatal SAM who showed histologic features in her aorta suggesting the opposite pathogenetic relationship, with an unclassified {"}FMD-like{"} arteriopathy preceding development of SAM.",

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AU - Gibson, Blake A.

AU - Hennemeyer, Charles T.

AU - Devis, Paola

AU - Black, Stacey

AU - Larsen, Brandon T.

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AB - Segmental arterial mediolysis (SAM) is a rare vasculopathy characterized by lysis of the outer media in splanchnic arteries and formation of dissecting pseudoaneurysms that may spontaneously rupture, leading to massive and often fatal intraabdominal hemorrhage. The pathogenesis of SAM is poorly understood. Healed SAM lesions closely resemble fibromuscular dysplasia (FMD), leading some authors to postulate that SAM represents a precursor to FMD despite distinct clinical differences between these two disorders. Herein, we present a 61-year-old woman with fatal SAM who showed histologic features in her aorta suggesting the opposite pathogenetic relationship, with an unclassified "FMD-like" arteriopathy preceding development of SAM.

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Segmental arterial mediolysis and fibromuscular dysplasia: What comes first, the chicken or the egg?

Abstract

Keywords

ASJC Scopus subject areas

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