Segmental analysis of sodium reabsorption during renal vein constriction

J. C. Burnett, J. A. Haas, F. G. Knox

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Clearance and micropuncture studies were performed in rats to identify the nephron sit(s) of altered sodium reabsorption during partial renal vein constriction in the presence and absence of volume expansion. Renal vein constriction increased fractional delivery of sodium to the late proximal tubule from 52±3 to 61±4% in euvolemia and from 59±3 to 65±3% in volume expansion. In euvolemia, fractional delivery of sodium to the early distal tubule was 13±3% before and 24±6% after renal vein constriction. In volume expansion, fractional delivery of sodium to the early distal tubule decreased from 15±3 to 9±2% in response to renal vein constriction. We conclude that renal vein constriction decreases sodium reabsorption by the proximal tubule both in euvolemia and in volume expansion but that it increases sodium reabsorption by the superficial loop of Henle only in the presence of volume expansion.

Original languageEnglish (US)
Pages (from-to)F19-F22
JournalAmerican Journal of Physiology - Renal Fluid and Electrolyte Physiology
Volume12
Issue number1
DOIs
StatePublished - 1982

ASJC Scopus subject areas

  • Physiology

Fingerprint Dive into the research topics of 'Segmental analysis of sodium reabsorption during renal vein constriction'. Together they form a unique fingerprint.

  • Cite this