Secular Trends in Renal Dysfunction and Outcomes in Hospitalized Heart Failure Patients

Theophilus E. Owan, David O. Hodge, Regina M. Herges, Steven J. Jacobsen, Veronique Lee Roger, Margaret May Redfield

Research output: Contribution to journalArticle

86 Citations (Scopus)

Abstract

Background: Renal dysfunction and worsening renal function (WRF) during heart failure (HF) therapy predict outcomes. We determined whether the severity of renal dysfunction, the incidence of WRF or outcomes have changed over time (secular trends) in patients hospitalized for HF therapy. Methods and Results: A total of 6440 consecutive unique patients admitted for HF to Mayo Clinic Hospitals Rochester, MN, January 1, 1987, to December 31, 2002, were identified and data extracted from electronic databases. Over the study period, age and admission creatinine increased, whereas estimated glomerular filtration rate and hemoglobin decreased (P < .0001 for all). The prevalence of hypertension and diabetes among HF patients also increased over time (P < .0001). The incidence of WRF was stable. Renal dysfunction and development of WRF were associated with mortality. When adjusted for the changes in baseline characteristics of HF patients, mortality declined over the study period. Conclusion: Hospitalized HF patients are increasingly elderly, have a greater prevalence of diseases that lead to renal dysfunction, and have more severe renal dysfunction and anemia on admission. However, adjusting for these secular trends in patient characteristics, mortality after HF admission is improving. These data enhance our understanding of the changing natural history of HF.

Original languageEnglish (US)
Pages (from-to)257-262
Number of pages6
JournalJournal of Cardiac Failure
Volume12
Issue number4
DOIs
StatePublished - May 2006
Externally publishedYes

Fingerprint

Heart Failure
Kidney
Mortality
Incidence
Glomerular Filtration Rate
Anemia
Creatinine
Databases
Hypertension
Therapeutics

Keywords

  • Community
  • Creatinine
  • Echocardiogram
  • Epidemiology

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Secular Trends in Renal Dysfunction and Outcomes in Hospitalized Heart Failure Patients. / Owan, Theophilus E.; Hodge, David O.; Herges, Regina M.; Jacobsen, Steven J.; Roger, Veronique Lee; Redfield, Margaret May.

In: Journal of Cardiac Failure, Vol. 12, No. 4, 05.2006, p. 257-262.

Research output: Contribution to journalArticle

Owan, Theophilus E. ; Hodge, David O. ; Herges, Regina M. ; Jacobsen, Steven J. ; Roger, Veronique Lee ; Redfield, Margaret May. / Secular Trends in Renal Dysfunction and Outcomes in Hospitalized Heart Failure Patients. In: Journal of Cardiac Failure. 2006 ; Vol. 12, No. 4. pp. 257-262.
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