Secondhand tobacco smoke exposure and lung adenocarcinoma in situ/minimally invasive adenocarcinoma (AIS/MIA)

Claire H. Kim, Yuan Chin Amy Lee, Rayjean J. Hung, Paolo Boffetta, Dong Xie, Jason A. Wampfler, Michele L. Cote, Shen Chih Chang, Donatella Ugolini, Monica Neri, Loic Le Marchand, Ann G. Schwartz, Hal Morgenstern, David C. Christiani, Ping Yang, Zuo Feng Zhang

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The aim of this study was to estimate the effect of exposure to secondhand tobacco smoke on the incidence of lung adenocarcinoma in situ/minimally invasive adenocarcinoma (AIS/ MIA). Data from seven case-control studies participating in the International Lung Cancer Consortium (ILCCO) were pooled, resulting in 625 cases of AIS/MIA and 7, 403 controls, of whom 170 cases and 3, 035 controls were never smokers. Unconditional logistic regression was used to estimate adjusted ORs (ORadj) and 95% confidence intervals (CI), controlling for age, sex, race, smoking status (ever/never), and pack-years of smoking. Study center was included in the models as a randomeffects intercept term. Ever versus never exposure to secondhand tobacco smoke was positively associated with AIS/MIA incidence in all subjects (ORadj = 1.48; 95%CI, 1.14-1.93) and in never smokers (ORadj = 1.45; 95% CI, 1.00-2.12). There was, however, appreciable heterogeneity of ORadj across studies (P = 0.01), and the pooled estimates were largely influenced by one large study (40% of all cases and 30% of all controls). These findings provide weak evidence for an effect of secondhand tobacco smoke exposure on AIS/MIA incidence. Further studies are needed to assess the impact of secondhand tobacco smoke exposure using the newly recommended classification of subtypes of lung adenocarcinoma. Cancer Epidemiol Biomarkers Prev; 24(12); 1902-6.

Original languageEnglish (US)
Pages (from-to)1902-1906
Number of pages5
JournalCancer Epidemiology Biomarkers and Prevention
Volume24
Issue number12
DOIs
StatePublished - Dec 1 2015

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Tobacco Smoke Pollution
Tobacco
Adenocarcinoma
Confidence Intervals
Incidence
Smoking
Tumor Biomarkers
Case-Control Studies
Lung Neoplasms
Logistic Models
Adenocarcinoma in Situ
Adenocarcinoma of lung

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

Secondhand tobacco smoke exposure and lung adenocarcinoma in situ/minimally invasive adenocarcinoma (AIS/MIA). / Kim, Claire H.; Lee, Yuan Chin Amy; Hung, Rayjean J.; Boffetta, Paolo; Xie, Dong; Wampfler, Jason A.; Cote, Michele L.; Chang, Shen Chih; Ugolini, Donatella; Neri, Monica; Le Marchand, Loic; Schwartz, Ann G.; Morgenstern, Hal; Christiani, David C.; Yang, Ping; Zhang, Zuo Feng.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 24, No. 12, 01.12.2015, p. 1902-1906.

Research output: Contribution to journalArticle

Kim, CH, Lee, YCA, Hung, RJ, Boffetta, P, Xie, D, Wampfler, JA, Cote, ML, Chang, SC, Ugolini, D, Neri, M, Le Marchand, L, Schwartz, AG, Morgenstern, H, Christiani, DC, Yang, P & Zhang, ZF 2015, 'Secondhand tobacco smoke exposure and lung adenocarcinoma in situ/minimally invasive adenocarcinoma (AIS/MIA)', Cancer Epidemiology Biomarkers and Prevention, vol. 24, no. 12, pp. 1902-1906. https://doi.org/10.1158/1055-9965.EPI-15-0436
Kim, Claire H. ; Lee, Yuan Chin Amy ; Hung, Rayjean J. ; Boffetta, Paolo ; Xie, Dong ; Wampfler, Jason A. ; Cote, Michele L. ; Chang, Shen Chih ; Ugolini, Donatella ; Neri, Monica ; Le Marchand, Loic ; Schwartz, Ann G. ; Morgenstern, Hal ; Christiani, David C. ; Yang, Ping ; Zhang, Zuo Feng. / Secondhand tobacco smoke exposure and lung adenocarcinoma in situ/minimally invasive adenocarcinoma (AIS/MIA). In: Cancer Epidemiology Biomarkers and Prevention. 2015 ; Vol. 24, No. 12. pp. 1902-1906.
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AU - Xie, Dong

AU - Wampfler, Jason A.

AU - Cote, Michele L.

AU - Chang, Shen Chih

AU - Ugolini, Donatella

AU - Neri, Monica

AU - Le Marchand, Loic

AU - Schwartz, Ann G.

AU - Morgenstern, Hal

AU - Christiani, David C.

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AB - The aim of this study was to estimate the effect of exposure to secondhand tobacco smoke on the incidence of lung adenocarcinoma in situ/minimally invasive adenocarcinoma (AIS/ MIA). Data from seven case-control studies participating in the International Lung Cancer Consortium (ILCCO) were pooled, resulting in 625 cases of AIS/MIA and 7, 403 controls, of whom 170 cases and 3, 035 controls were never smokers. Unconditional logistic regression was used to estimate adjusted ORs (ORadj) and 95% confidence intervals (CI), controlling for age, sex, race, smoking status (ever/never), and pack-years of smoking. Study center was included in the models as a randomeffects intercept term. Ever versus never exposure to secondhand tobacco smoke was positively associated with AIS/MIA incidence in all subjects (ORadj = 1.48; 95%CI, 1.14-1.93) and in never smokers (ORadj = 1.45; 95% CI, 1.00-2.12). There was, however, appreciable heterogeneity of ORadj across studies (P = 0.01), and the pooled estimates were largely influenced by one large study (40% of all cases and 30% of all controls). These findings provide weak evidence for an effect of secondhand tobacco smoke exposure on AIS/MIA incidence. Further studies are needed to assess the impact of secondhand tobacco smoke exposure using the newly recommended classification of subtypes of lung adenocarcinoma. Cancer Epidemiol Biomarkers Prev; 24(12); 1902-6.

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