Secondary Philadelphia chromosome and erythrophagocytosis in a relapsed acute myeloid leukemia after hematopoietic cell transplantation

Katalin Kelemen, Komal Galani, Christopher R. Conley, Patricia T. Greipp

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

The acquisition of the Philadelphia chromosome (Ph) as a secondary change during the course of hematopoietic malignancies is rare and is associated with poor prognosis. Few cases of secondary Ph have been reported after hematopoietic cell transplantation (HCT). A secondary Ph at relapse is of clinical importance because it provides a therapeutic target for tyrosine kinase inhibitors along with or in replacement of chemotherapy. We describe a case of relapsed acute myeloid leukemia (AML) after HCT that developed a BCR-ABL1 translocation along with erythrophagocytosis by blasts as a secondary change at the time of relapse. The progression of this patient's myeloid neoplasm from myelodysplastic syndrome to AML to relapsed AML after HCT was accompanied by a stepwise cytogenetic evolution: A deletion 20q abnormality subsequently acquired a deletion 7q and, finally, at relapse after HCT, a secondary Ph was gained. The relationship between the secondary Ph and the erythrophagocytosis by blasts is not clear. We review the possible pathogenesis and cytogenetic associations of erythrophagocytosis by blasts, a rare feature in acute leukemias.

Original languageEnglish (US)
Pages (from-to)268-271
Number of pages4
JournalCancer Genetics
Volume207
Issue number6
DOIs
StatePublished - Jun 1 2014

Keywords

  • Acute myeloid leukemia
  • Erythrophagocytosis
  • Hematopoietic cell transplantation
  • Secondary Philadelphia chromosome

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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