Screening for lung cancer with low-dose spiral computed tomography

Stephen J. Swensen, James R. Jett, Jeff A Sloan, David Eric Midthun, Thomas E. Hartman, Anne-Marie Gisele Sykes, Gregory L. Aughenbaugh, Frank E. Zink, Shauna L. Hillman, Gayle R. Noetzel, Randolph Stuart Marks, Amy C. Clayton, Peter C. Pairolero

Research output: Contribution to journalArticle

572 Citations (Scopus)

Abstract

Studies suggest that screening with spiral computed tomography can detect lung cancers at a smaller size and earlier stage than chest radiography can. To evaluate low-radiation-dose spiral computed tomography and sputum cytology in screening for lung cancer, we enrolled 1,520 individuals aged 50 yr or older who had smoked 20 pack-years or more in a prospective cohort study. One year after baseline scanning, 2,244 uncalcified lung nodules were identified in 1,000 participants (66%). Twenty-five cases of lung cancer were diagnosed (22 prevalence, 3 incidence). Computed tomography alone detected 23 cases; sputum cytology alone detected 2 cases. Cell types were: Squamous cell, 6; adenocarcinoma or bronchioalveolar, 15; large cell, 1; small cell, 3. Twenty-two patients underwent curative surgical resection. Seven benign nodules were resected. The mean size of the non-small cell cancers detected by computed tomography was 17 mm (median, 13 mm). The postsurgical stage was IA, 13; IB, 1; IIA, 5; IIB, 1; IIIA, 2; limited, 3. Twelve (57%) of the 21 non-small cell cancers detected by computed tomography were stage IA at diagnosis. Computed tomography can detect early-stage lung cancers. The rate of benign nodule detection is high.

Original languageEnglish (US)
Pages (from-to)508-513
Number of pages6
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume165
Issue number4
StatePublished - Feb 15 2002

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Spiral Computed Tomography
Lung Neoplasms
Tomography
Sputum
Cell Biology
Radiography
Neoplasms
Adenocarcinoma
Cohort Studies
Thorax
Epithelial Cells
Prospective Studies
Radiation
Lung
Incidence

Keywords

  • Carcinoma
  • Cytology
  • Non-small cell lung
  • Smoking
  • Tomography
  • X-ray computed

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Screening for lung cancer with low-dose spiral computed tomography. / Swensen, Stephen J.; Jett, James R.; Sloan, Jeff A; Midthun, David Eric; Hartman, Thomas E.; Sykes, Anne-Marie Gisele; Aughenbaugh, Gregory L.; Zink, Frank E.; Hillman, Shauna L.; Noetzel, Gayle R.; Marks, Randolph Stuart; Clayton, Amy C.; Pairolero, Peter C.

In: American Journal of Respiratory and Critical Care Medicine, Vol. 165, No. 4, 15.02.2002, p. 508-513.

Research output: Contribution to journalArticle

Swensen, SJ, Jett, JR, Sloan, JA, Midthun, DE, Hartman, TE, Sykes, A-MG, Aughenbaugh, GL, Zink, FE, Hillman, SL, Noetzel, GR, Marks, RS, Clayton, AC & Pairolero, PC 2002, 'Screening for lung cancer with low-dose spiral computed tomography', American Journal of Respiratory and Critical Care Medicine, vol. 165, no. 4, pp. 508-513.
Swensen, Stephen J. ; Jett, James R. ; Sloan, Jeff A ; Midthun, David Eric ; Hartman, Thomas E. ; Sykes, Anne-Marie Gisele ; Aughenbaugh, Gregory L. ; Zink, Frank E. ; Hillman, Shauna L. ; Noetzel, Gayle R. ; Marks, Randolph Stuart ; Clayton, Amy C. ; Pairolero, Peter C. / Screening for lung cancer with low-dose spiral computed tomography. In: American Journal of Respiratory and Critical Care Medicine. 2002 ; Vol. 165, No. 4. pp. 508-513.
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