Scrambler Therapy for the management of chronic pain

Neil Majithia, Thomas J. Smith, Patrick J. Coyne, Salahadin Abdi, Deirdre R. Pachman, Daniel H Lachance, Randy Shelerud, Andrea L Cheville, Jeffrey R. Basford, David Farley, Carrie O’Neill, Kathryn J Ruddy, Frank Sparadeo, Andreas S Beutler, Charles Lawrence Loprinzi

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Purpose: Chronic pain is a widespread and debilitating condition, encountered by physicians in a variety of practice settings. Although many pharmacologic and behavioral strategies exist for the management of this condition, treatment is often unsatisfactory. Scrambler Therapy is a novel, non-invasive pain modifying technique that utilizes trans-cutaneous electrical stimulation of pain fibers with the intent of re-organizing maladaptive signaling pathways. This review was conducted to further evaluate what is known regarding the mechanisms and mechanics of Scrambler Therapy and to investigate the preliminary data pertaining to the efficacy of this treatment modality. Methods: The PubMed/Medline, SCOPUS, EMBASE, and Google Scholar databases were searched for all articles published on Scrambler Therapy prior to November 2015. All case studies and clinical trials were evaluated and reported in a descriptive manner. Results: To date, 20 reports, of varying scientific quality, have been published regarding this device; all but one small study, published only as an abstract, provided results that appear positive. Conclusion: The positive findings from preliminary studies with Scrambler Therapy support that this device provides benefit for patients with refractory pain syndromes. Larger, randomized studies are required to further evaluate the efficacy of this approach.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalSupportive Care in Cancer
DOIs
StateAccepted/In press - Apr 4 2016

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Chronic Pain
Therapeutics
Pain
Intractable Pain
Equipment and Supplies
Mechanics
PubMed
Electric Stimulation
Clinical Trials
Databases
Physicians
Skin

Keywords

  • Chemotherapy-induced peripheral neuropathy
  • Chronic pain
  • Pain
  • Scrambler Therapy

ASJC Scopus subject areas

  • Oncology

Cite this

Scrambler Therapy for the management of chronic pain. / Majithia, Neil; Smith, Thomas J.; Coyne, Patrick J.; Abdi, Salahadin; Pachman, Deirdre R.; Lachance, Daniel H; Shelerud, Randy; Cheville, Andrea L; Basford, Jeffrey R.; Farley, David; O’Neill, Carrie; Ruddy, Kathryn J; Sparadeo, Frank; Beutler, Andreas S; Loprinzi, Charles Lawrence.

In: Supportive Care in Cancer, 04.04.2016, p. 1-8.

Research output: Contribution to journalArticle

Majithia, N, Smith, TJ, Coyne, PJ, Abdi, S, Pachman, DR, Lachance, DH, Shelerud, R, Cheville, AL, Basford, JR, Farley, D, O’Neill, C, Ruddy, KJ, Sparadeo, F, Beutler, AS & Loprinzi, CL 2016, 'Scrambler Therapy for the management of chronic pain', Supportive Care in Cancer, pp. 1-8. https://doi.org/10.1007/s00520-016-3177-3
Majithia, Neil ; Smith, Thomas J. ; Coyne, Patrick J. ; Abdi, Salahadin ; Pachman, Deirdre R. ; Lachance, Daniel H ; Shelerud, Randy ; Cheville, Andrea L ; Basford, Jeffrey R. ; Farley, David ; O’Neill, Carrie ; Ruddy, Kathryn J ; Sparadeo, Frank ; Beutler, Andreas S ; Loprinzi, Charles Lawrence. / Scrambler Therapy for the management of chronic pain. In: Supportive Care in Cancer. 2016 ; pp. 1-8.
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