Sclerostin expression and functions beyond the osteocyte

Megan Weivoda, Stephanie J. Youssef, Merry Jo Oursler

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Sclerostin, the product of the . SOST gene, is a secreted inhibitor of Wnt signaling that is produced by osteocytes to regulate bone formation. While it is often considered an osteocyte-specific protein, . SOST expression has been reported in numerous other cell types, including hypertrophic chondrocytes and cementocytes. Of interest, . SOST/sclerostin expression is altered in certain pathogenic conditions, including osteoarthritis and rheumatic joint disease, and it is unclear whether sclerostin plays a protective role or whether sclerostin may mediate disease pathogenesis. Therefore, as anti-sclerostin antibodies are being developed for the treatment of osteoporosis, it is important to understand the functions of sclerostin beyond the regulation of bone formation.

Original languageEnglish (US)
JournalBone
DOIs
StateAccepted/In press - Jun 14 2016

Keywords

  • Ankylosing spondylitis
  • Osteoarthritis
  • Rheumatoid arthritis
  • Sclerostin
  • Wnt

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Histology
  • Physiology

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