Sclerostin expression and functions beyond the osteocyte

Megan M. Weivoda, Stephanie J. Youssef, Merry Jo Oursler

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

Sclerostin, the product of the SOST gene, is a secreted inhibitor of Wnt signaling that is produced by osteocytes to regulate bone formation. While it is often considered an osteocyte-specific protein, SOST expression has been reported in numerous other cell types, including hypertrophic chondrocytes and cementocytes. Of interest, SOST/sclerostin expression is altered in certain pathogenic conditions, including osteoarthritis and rheumatic joint disease, and it is unclear whether sclerostin plays a protective role or whether sclerostin may mediate disease pathogenesis. Therefore, as anti-sclerostin antibodies are being developed for the treatment of osteoporosis, it is important to understand the functions of sclerostin beyond the regulation of bone formation.

Original languageEnglish (US)
Pages (from-to)45-50
Number of pages6
JournalBone
Volume96
DOIs
StatePublished - Mar 1 2017

Keywords

  • Ankylosing spondylitis
  • Osteoarthritis
  • Rheumatoid arthritis
  • Sclerostin
  • Wnt

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Histology

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