Sclerosing angiomatoid nodular transformation of the spleen: CT, MR, PET, and 99mTc-sulfur colloid SPECT CT findings with gross and histopathological correlation

Curtis Thacker, Ronald Korn, John Millstine, Howard Harvin, Jeffrey A. Van Lier Ribbink, Michael B. Gotway

Research output: Contribution to journalArticle

35 Scopus citations


Sclerosing angiomatoid nodular transformation (SANT) is a benign, proliferative vascular lesion affecting the spleen. Few reports detailing the cross sectional and PET appearance of this lesion are available, and the lesion's behavior with 99mTc-sulfur colloid scintigraphy is previously unreported. Sclerosing nodular transformation of the spleen shows increased tracer accumulation on positron emission tomography, and a central scar-like appearance with an enhancing capsule and radiating septae on CT and MR studies that reflects the gross and histopathological features of the lesion may be visible. An understanding of this pathological finding may allow prospective recognition of the sclerosing nodular transformation of the spleen on cross sectional imaging studies.

Original languageEnglish (US)
Pages (from-to)683-689
Number of pages7
JournalAbdominal Imaging
Issue number6
StatePublished - Dec 1 2010



  • Mass
  • Positron emission tomography
  • Proliferation
  • Sclerosing angiomatoid nodular transformation
  • Spleen
  • Sulfur colloid
  • Vascular lesion

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Gastroenterology
  • Urology

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