Scleroderma Induced by Pembrolizumab: A Case Series

Naiara S. Barbosa; David A. Wetter; Carilyn N. Wieland; Niraj K. Shenoy; Svetomir N. Markovic; Uma Thanarajasingam

doi:10.1016/j.mayocp.2017.03.016

Scleroderma Induced by Pembrolizumab: A Case Series

Naiara S. Barbosa, David A. Wetter, Carilyn N. Wieland, Niraj K. Shenoy, Svetomir N. Markovic, Uma Thanarajasingam

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

Immune checkpoint inhibitors are approved for select cancer treatment and have shown survival benefit in patients with advanced melanoma. Adverse events, including immune-related adverse events, are common and potentially life-threatening. We describe cases of 2 patients with scleroderma (patient 1 had diffuse scleroderma, and patient 2 had limited scleroderma) that developed while they were receiving pembrolizumab therapy for metastatic melanoma. Prompt recognition and treatment of immune-related adverse events may improve tolerance to immune checkpoint inhibitors and contribute to an understanding of the manifesting autoimmune disease.

Original language	English (US)
Pages (from-to)	1158-1163
Number of pages	6
Journal	Mayo Clinic proceedings
Volume	92
Issue number	7
DOIs	https://doi.org/10.1016/j.mayocp.2017.03.016
State	Published - Jul 2017

ASJC Scopus subject areas

General Medicine

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title = "Scleroderma Induced by Pembrolizumab: A Case Series",

abstract = "Immune checkpoint inhibitors are approved for select cancer treatment and have shown survival benefit in patients with advanced melanoma. Adverse events, including immune-related adverse events, are common and potentially life-threatening. We describe cases of 2 patients with scleroderma (patient 1 had diffuse scleroderma, and patient 2 had limited scleroderma) that developed while they were receiving pembrolizumab therapy for metastatic melanoma. Prompt recognition and treatment of immune-related adverse events may improve tolerance to immune checkpoint inhibitors and contribute to an understanding of the manifesting autoimmune disease.",

author = "Barbosa, {Naiara S.} and Wetter, {David A.} and Wieland, {Carilyn N.} and Shenoy, {Niraj K.} and Markovic, {Svetomir N.} and Uma Thanarajasingam",

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year = "2017",

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AU - Barbosa, Naiara S.

AU - Wetter, David A.

AU - Wieland, Carilyn N.

AU - Shenoy, Niraj K.

AU - Markovic, Svetomir N.

AU - Thanarajasingam, Uma

PY - 2017/7

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N2 - Immune checkpoint inhibitors are approved for select cancer treatment and have shown survival benefit in patients with advanced melanoma. Adverse events, including immune-related adverse events, are common and potentially life-threatening. We describe cases of 2 patients with scleroderma (patient 1 had diffuse scleroderma, and patient 2 had limited scleroderma) that developed while they were receiving pembrolizumab therapy for metastatic melanoma. Prompt recognition and treatment of immune-related adverse events may improve tolerance to immune checkpoint inhibitors and contribute to an understanding of the manifesting autoimmune disease.

AB - Immune checkpoint inhibitors are approved for select cancer treatment and have shown survival benefit in patients with advanced melanoma. Adverse events, including immune-related adverse events, are common and potentially life-threatening. We describe cases of 2 patients with scleroderma (patient 1 had diffuse scleroderma, and patient 2 had limited scleroderma) that developed while they were receiving pembrolizumab therapy for metastatic melanoma. Prompt recognition and treatment of immune-related adverse events may improve tolerance to immune checkpoint inhibitors and contribute to an understanding of the manifesting autoimmune disease.

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Scleroderma Induced by Pembrolizumab: A Case Series

Abstract

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