TY - JOUR
T1 - Scintigraphic biomarkers for colonic dysmotility
AU - Camilleri, M.
PY - 2010/6
Y1 - 2010/6
N2 - Scintigraphic colonic transit measurement has emerged as a unique disease-related biomarker pertinent to drug development and personalized therapy. This surrogate offers reproducible and accurate performance across a spectrum of common colonic motility disorders, linking colonic transit measurements to biological processes and clinical end points. The pathobiologic validity, prognostic utility, performance characteristics, evidence-based linkage of therapeutic intervention with outcome, applicability across distinct pharmacodynamic profiles, and potential for individualizing patient management are all attributes of this gastrointestinal imaging paradigm. The cumulative evidence suggests that the integration of colonic transit measurement as a biomarker would accelerate the development and regulatory approval of therapeutic agents for the treatment of colonic dysmotility.
AB - Scintigraphic colonic transit measurement has emerged as a unique disease-related biomarker pertinent to drug development and personalized therapy. This surrogate offers reproducible and accurate performance across a spectrum of common colonic motility disorders, linking colonic transit measurements to biological processes and clinical end points. The pathobiologic validity, prognostic utility, performance characteristics, evidence-based linkage of therapeutic intervention with outcome, applicability across distinct pharmacodynamic profiles, and potential for individualizing patient management are all attributes of this gastrointestinal imaging paradigm. The cumulative evidence suggests that the integration of colonic transit measurement as a biomarker would accelerate the development and regulatory approval of therapeutic agents for the treatment of colonic dysmotility.
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U2 - 10.1038/clpt.2010.23
DO - 10.1038/clpt.2010.23
M3 - Review article
C2 - 20410880
AN - SCOPUS:77952581741
SN - 0009-9236
VL - 87
SP - 748
EP - 753
JO - Clinical pharmacology and therapeutics
JF - Clinical pharmacology and therapeutics
IS - 6
ER -