TY - JOUR
T1 - Scientific opportunities in resilience research for cardiovascular health and wellness. Report from a National Heart, Lung, and Blood Institute workshop
AU - Taylor, Herman A.
AU - Finkel, Toren
AU - Gao, Yunling
AU - Ballinger, Scott W.
AU - Campo, Rebecca
AU - Chen, Rong
AU - Chen, Shu Hui
AU - Davidson, Karina
AU - Iruela-Arispe, M. Luisa
AU - Jaquish, Cashell
AU - LeBrasseur, Nathan K.
AU - Odden, Michelle C.
AU - Papanicolaou, George J.
AU - Picard, Martin
AU - Srinivas, Pothur
AU - Tjurmina, Olga
AU - Wolz, Michael
AU - Galis, Zorina S.
N1 - Funding Information:
The workshop Enhancing Resilience for Cardiovascular Health and Wellness was supported by the NHLBI, NIH. Dr. Taylor was supported by AHA grant 0000031288 and NIH grant P50 HL117929. Dr. Finkel was supported by NIH grant P30 AG024827; R01 HL14266; R01 HL142589 and U54 AG075931. Dr. Chen was supported by NIH grant UG3 TR004040. Dr. LeBrasseur was supported by NIH grants R01 AG53832, U54 AG44170, and P01 AG62413. Dr. Ballinger was supported by NIH grants R01 HL103859 and T32 HL007918. Dr. Iruela-Arispe was supported by NIH grants R35 HL140014. Dr. Odden was supported by NIH grants R21 HL135195, R01 AG046206, R01 AG062568, R01 AG071019, R01 HL151564. Dr. Davidson was supported by NIH grants R24 AG064191 and R01 LM012836. Dr. Picard was supported by NIH grants R01 MH119336, R01 MH122706, R01 AG066828, R21 MH123927, and the Wharton Fund. The authors thank their colleague Dr. Charles Nicholas Serhan (Brigham & Women's Health, Harvard University) for assisting with workshop presentations and Drs. Kathleen Fenton and Laurie Donze (NHLBI) for critical reading and suggestions for the manuscript.
Funding Information:
The workshop was supported by the NHLBI, NIH. Dr. Taylor was supported by AHA grant 0000031288 and NIH grant P50 HL117929. Dr. Finkel was supported by NIH grant P30 AG024827; R01 HL14266; R01 HL142589 and U54 AG075931. Dr. Chen was supported by NIH grant UG3 TR004040. Dr. LeBrasseur was supported by NIH grants R01 AG53832, U54 AG44170, and P01 AG62413. Dr. Ballinger was supported by NIH grants R01 HL103859 and T32 HL007918. Dr. Iruela‐Arispe was supported by NIH grants R35 HL140014. Dr. Odden was supported by NIH grants R21 HL135195, R01 AG046206, R01 AG062568, R01 AG071019, R01 HL151564. Dr. Davidson was supported by NIH grants R24 AG064191 and R01 LM012836. Dr. Picard was supported by NIH grants R01 MH119336, R01 MH122706, R01 AG066828, R21 MH123927, and the Wharton Fund. The authors thank their colleague Dr. Charles Nicholas Serhan (Brigham & Women's Health, Harvard University) for assisting with workshop presentations and Drs. Kathleen Fenton and Laurie Donze (NHLBI) for critical reading and suggestions for the manuscript. Enhancing Resilience for Cardiovascular Health and Wellness
Publisher Copyright:
© 2022 The Authors. The FASEB Journal published by Wiley Periodicals LLC on behalf of Federation of American Societies for Experimental Biology.
PY - 2022/12
Y1 - 2022/12
N2 - Exposure of biological systems to acute or chronic insults triggers a host of molecular and physiological responses to either tolerate, adapt, or fully restore homeostasis; these responses constitute the hallmarks of resilience. Given the many facets, dimensions, and discipline-specific focus, gaining a shared understanding of “resilience” has been identified as a priority for supporting advances in cardiovascular health. This report is based on the working definition: “Resilience is the ability of living systems to successfully maintain or return to homeostasis in response to physical, molecular, individual, social, societal, or environmental stressors or challenges,” developed after considering many factors contributing to cardiovascular resilience through deliberations of multidisciplinary experts convened by the National Heart, Lung, and Blood Institute during a workshop entitled: “Enhancing Resilience for Cardiovascular Health and Wellness.” Some of the main emerging themes that support the possibility of enhancing resilience for cardiovascular health include optimal energy management and substrate diversity, a robust immune system that safeguards tissue homeostasis, and social and community support. The report also highlights existing research challenges, along with immediate and long-term opportunities for resilience research. Certain immediate opportunities identified are based on leveraging existing high-dimensional data from longitudinal clinical studies to identify vascular resilience measures, create a ‘resilience index,’ and adopt a life-course approach. Long-term opportunities include developing quantitative cell/organ/system/community models to identify resilience factors and mechanisms at these various levels, designing experimental and clinical interventions that specifically assess resilience, adopting global sharing of resilience-related data, and cross-domain training of next-generation researchers in this field.
AB - Exposure of biological systems to acute or chronic insults triggers a host of molecular and physiological responses to either tolerate, adapt, or fully restore homeostasis; these responses constitute the hallmarks of resilience. Given the many facets, dimensions, and discipline-specific focus, gaining a shared understanding of “resilience” has been identified as a priority for supporting advances in cardiovascular health. This report is based on the working definition: “Resilience is the ability of living systems to successfully maintain or return to homeostasis in response to physical, molecular, individual, social, societal, or environmental stressors or challenges,” developed after considering many factors contributing to cardiovascular resilience through deliberations of multidisciplinary experts convened by the National Heart, Lung, and Blood Institute during a workshop entitled: “Enhancing Resilience for Cardiovascular Health and Wellness.” Some of the main emerging themes that support the possibility of enhancing resilience for cardiovascular health include optimal energy management and substrate diversity, a robust immune system that safeguards tissue homeostasis, and social and community support. The report also highlights existing research challenges, along with immediate and long-term opportunities for resilience research. Certain immediate opportunities identified are based on leveraging existing high-dimensional data from longitudinal clinical studies to identify vascular resilience measures, create a ‘resilience index,’ and adopt a life-course approach. Long-term opportunities include developing quantitative cell/organ/system/community models to identify resilience factors and mechanisms at these various levels, designing experimental and clinical interventions that specifically assess resilience, adopting global sharing of resilience-related data, and cross-domain training of next-generation researchers in this field.
KW - adaptation
KW - aging
KW - cardiovascular disease
KW - cardiovascular health
KW - genetic plasticity
KW - health disparities
KW - homeostasis
KW - resilience
KW - stress
UR - http://www.scopus.com/inward/record.url?scp=85141205219&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85141205219&partnerID=8YFLogxK
U2 - 10.1096/fj.202201407R
DO - 10.1096/fj.202201407R
M3 - Article
C2 - 36322029
AN - SCOPUS:85141205219
VL - 36
JO - FASEB Journal
JF - FASEB Journal
SN - 0892-6638
IS - 12
M1 - e22639
ER -