TY - JOUR
T1 - Schwarz meets Schwann
T2 - Design and fabrication of biomorphic and durataxic tissue engineering scaffolds
AU - Rajagopalan, Srinivasan
AU - Robb, Richard A.
N1 - Funding Information:
The first author would like to acknowledge the mentorship and intellectual freedom provided by Dr. Richard Robb. Such benevolence, though driven by an individual’s volition, spreads thin in the absence of individuals who recognize and exploit it to further the science. Both the authors acknowledge the longstanding association and contributions of their colleagues and members (Darlene Bernard, Margret Ryan, Dennis Hanson, Jon Camp, Kurt Augustine, Al Larson, Ellis Workman, Ron Karwoski, Bruce Cameron, Mark Korinek, Russ Moritz, and Phillip Edwards) of the Biomedical Imaging Resource. The authors also acknowledge the support of Drs. Michael Yaszemski, Lichun Lu and Mahrokh Dadestan from the tissue engineering and polymeric biomaterial laboratory. This research was supported by the Mayo Clinic College of Medicine.
PY - 2006/10
Y1 - 2006/10
N2 - Tissue engineering is a discipline at the leading edge of the field of computer assisted intervention. This multidisciplinary engineering science attempts to meet the reparative and regenerative needs of tissues and organs based on the notion of design and fabrication of scaffolds- porous, three-dimensional "trellis-like" biomimetic structures that, on implantation, provide a viable environment to recuperate and regenerate damaged cells. Existing scaffold fabrication strategies produce sub-optimal porous labyrinths with contra-naturam straight edges. The biomorphic geometry that mimics the secundam-naturam substrate would be one that is continuous through all space, partitioned into two not-necessarily-equal sub-spaces by a non-intersecting, two-sided surface. Minimal surface geometry is not only ideal to describe such a space but is also the preferentially assumed geometry in natural and pathological or manipulated cells. We present results on the premier attempt in computer-controlled fabrication, modulation, and mechanical characterization of tissue engineering scaffolds based on triply periodic minimal surfaces (TPMS). We also present novel strategies to realize coterminous seeding-feeding networks thereby guaranteeing blood/nutrient supply to the proliferating cells at close proximity. This initiative of linking Schwann's 1838 cell theory with Schwarz's 1865 discovery of TPMS is a significant step to fabricate the previously elusive optimal biomorphic tissue analogs.
AB - Tissue engineering is a discipline at the leading edge of the field of computer assisted intervention. This multidisciplinary engineering science attempts to meet the reparative and regenerative needs of tissues and organs based on the notion of design and fabrication of scaffolds- porous, three-dimensional "trellis-like" biomimetic structures that, on implantation, provide a viable environment to recuperate and regenerate damaged cells. Existing scaffold fabrication strategies produce sub-optimal porous labyrinths with contra-naturam straight edges. The biomorphic geometry that mimics the secundam-naturam substrate would be one that is continuous through all space, partitioned into two not-necessarily-equal sub-spaces by a non-intersecting, two-sided surface. Minimal surface geometry is not only ideal to describe such a space but is also the preferentially assumed geometry in natural and pathological or manipulated cells. We present results on the premier attempt in computer-controlled fabrication, modulation, and mechanical characterization of tissue engineering scaffolds based on triply periodic minimal surfaces (TPMS). We also present novel strategies to realize coterminous seeding-feeding networks thereby guaranteeing blood/nutrient supply to the proliferating cells at close proximity. This initiative of linking Schwann's 1838 cell theory with Schwarz's 1865 discovery of TPMS is a significant step to fabricate the previously elusive optimal biomorphic tissue analogs.
KW - Biomorphic
KW - Durataxic
KW - Minimal surfaces
KW - Scaffolds
KW - Solid freeform fabrication
KW - Tissue engineering
KW - Triply periodic minimal surfaces
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U2 - 10.1016/j.media.2006.06.001
DO - 10.1016/j.media.2006.06.001
M3 - Article
C2 - 16890007
AN - SCOPUS:33748622593
SN - 1361-8415
VL - 10
SP - 693
EP - 712
JO - Medical Image Analysis
JF - Medical Image Analysis
IS - 5
ER -