Schisandrin B protects against tacrine- and bis(7)-tacrine-induced hepatotoxicity and enhances cognitive function in mice

S. Y. Pan, Y. F. Han, P. R. Carlier, Y. P. Pang, D. H.F. Mak, B. Y.H. Lam, K. M. Ko

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Intragastric administration (100-200 μmol/kg) of tacrine (THA) or bis(7)-THA could cause an acute and dose-dependent increase in plasma alanine aminotransferases activity in mice at 6 h after the drug administration. The increase in plasma enzyme activity was associated with an increase in hepatic malondialdehyde level, an indirect index of oxidative tissue damage. Pretreating mice with schisandrin B (Sch B), an active dibenzocyclooctadiene derivative isolated from the fruit of Schisandra chinensis, at a daily dose of 0.125-0.5 mmol/kg for 3 days protected against the THA/bis(7)-THA induced hepatic oxidative damage in a dose-dependent manner. Sch B treatment (0.025-0.5 mmol/kg/day × 5) also enhanced the passive avoidance-response in mice as assessed by the step-through task experiment. The ensemble of results suggests that Sch B may be useful for reducing the potential hepatotoxicity of THA/bis(7)-THA in anti-Alzheimer's therapy.

Original languageEnglish (US)
Pages (from-to)217-220
Number of pages4
JournalPlanta Medica
Volume68
Issue number3
DOIs
StatePublished - Apr 13 2002

Keywords

  • Bis(7)-tacrine
  • Cognitive enhancement
  • Hepatotoxicity
  • Schisandra chinensis
  • Schisandraceae
  • Schisandrin B
  • Tacrine

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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