Scaffolds for tissue engineering of cardiac valves

S. Jana, B. J. Tefft, D. B. Spoon, R. D. Simari

Research output: Contribution to journalReview article

89 Scopus citations

Abstract

Tissue engineered heart valves offer a promising alternative for the replacement of diseased heart valves avoiding the limitations faced with currently available bioprosthetic and mechanical heart valves. In the paradigm of tissue engineering, a three-dimensional platform - the so-called scaffold - is essential for cell proliferation, growth and differentiation, as well as the ultimate generation of a functional tissue. A foundation for success in heart valve tissue engineering is a recapitulation of the complex design and diverse mechanical properties of a native valve. This article reviews technological details of the scaffolds that have been applied to date in heart valve tissue engineering research.

Original languageEnglish (US)
Pages (from-to)2877-2893
Number of pages17
JournalActa Biomaterialia
Volume10
Issue number7
DOIs
StatePublished - Jul 2014

    Fingerprint

Keywords

  • Fiber
  • Heart valve
  • Hydrogel
  • Scaffold
  • Tissue engineering

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Biochemistry
  • Biomedical Engineering
  • Molecular Biology

Cite this