Scaffolds for tissue engineering of cardiac valves

S. Jana; B. J. Tefft; D. B. Spoon; R. D. Simari

doi:10.1016/j.actbio.2014.03.014

Scaffolds for tissue engineering of cardiac valves

S. Jana, B. J. Tefft, D. B. Spoon, R. D. Simari

Cardiovascular Medicine

Research output: Contribution to journal › Review article › peer-review

102 Scopus citations

Abstract

Tissue engineered heart valves offer a promising alternative for the replacement of diseased heart valves avoiding the limitations faced with currently available bioprosthetic and mechanical heart valves. In the paradigm of tissue engineering, a three-dimensional platform - the so-called scaffold - is essential for cell proliferation, growth and differentiation, as well as the ultimate generation of a functional tissue. A foundation for success in heart valve tissue engineering is a recapitulation of the complex design and diverse mechanical properties of a native valve. This article reviews technological details of the scaffolds that have been applied to date in heart valve tissue engineering research.

Original language	English (US)
Pages (from-to)	2877-2893
Number of pages	17
Journal	Acta Biomaterialia
Volume	10
Issue number	7
DOIs	https://doi.org/10.1016/j.actbio.2014.03.014
State	Published - Jul 2014

Keywords

Fiber
Heart valve
Hydrogel
Scaffold
Tissue engineering

ASJC Scopus subject areas

Biotechnology
Biomaterials
Biochemistry
Biomedical Engineering
Molecular Biology

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10.1016/j.actbio.2014.03.014

Cite this

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title = "Scaffolds for tissue engineering of cardiac valves",

abstract = "Tissue engineered heart valves offer a promising alternative for the replacement of diseased heart valves avoiding the limitations faced with currently available bioprosthetic and mechanical heart valves. In the paradigm of tissue engineering, a three-dimensional platform - the so-called scaffold - is essential for cell proliferation, growth and differentiation, as well as the ultimate generation of a functional tissue. A foundation for success in heart valve tissue engineering is a recapitulation of the complex design and diverse mechanical properties of a native valve. This article reviews technological details of the scaffolds that have been applied to date in heart valve tissue engineering research.",

keywords = "Fiber, Heart valve, Hydrogel, Scaffold, Tissue engineering",

author = "S. Jana and Tefft, {B. J.} and Spoon, {D. B.} and Simari, {R. D.}",

note = "Funding Information: This work is supported by the HH Sheikh Hamed bin Zayed Al Nahyan Program in Biological Valve Engineering , the Grainger Foundation , and the Mayo Clinic Center for Regenerative Medicine . ",

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AU - Jana, S.

AU - Tefft, B. J.

AU - Spoon, D. B.

AU - Simari, R. D.

N1 - Funding Information: This work is supported by the HH Sheikh Hamed bin Zayed Al Nahyan Program in Biological Valve Engineering , the Grainger Foundation , and the Mayo Clinic Center for Regenerative Medicine .

PY - 2014/7

Y1 - 2014/7

N2 - Tissue engineered heart valves offer a promising alternative for the replacement of diseased heart valves avoiding the limitations faced with currently available bioprosthetic and mechanical heart valves. In the paradigm of tissue engineering, a three-dimensional platform - the so-called scaffold - is essential for cell proliferation, growth and differentiation, as well as the ultimate generation of a functional tissue. A foundation for success in heart valve tissue engineering is a recapitulation of the complex design and diverse mechanical properties of a native valve. This article reviews technological details of the scaffolds that have been applied to date in heart valve tissue engineering research.

AB - Tissue engineered heart valves offer a promising alternative for the replacement of diseased heart valves avoiding the limitations faced with currently available bioprosthetic and mechanical heart valves. In the paradigm of tissue engineering, a three-dimensional platform - the so-called scaffold - is essential for cell proliferation, growth and differentiation, as well as the ultimate generation of a functional tissue. A foundation for success in heart valve tissue engineering is a recapitulation of the complex design and diverse mechanical properties of a native valve. This article reviews technological details of the scaffolds that have been applied to date in heart valve tissue engineering research.

KW - Fiber

KW - Heart valve

KW - Hydrogel

KW - Scaffold

KW - Tissue engineering

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Scaffolds for tissue engineering of cardiac valves

Abstract

Keywords

ASJC Scopus subject areas

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