Scaffolds for tissue engineering of cardiac valves

Soumen Jana, B. J. Tefft, D. B. Spoon, R. D. Simari

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

Tissue engineered heart valves offer a promising alternative for the replacement of diseased heart valves avoiding the limitations faced with currently available bioprosthetic and mechanical heart valves. In the paradigm of tissue engineering, a three-dimensional platform - the so-called scaffold - is essential for cell proliferation, growth and differentiation, as well as the ultimate generation of a functional tissue. A foundation for success in heart valve tissue engineering is a recapitulation of the complex design and diverse mechanical properties of a native valve. This article reviews technological details of the scaffolds that have been applied to date in heart valve tissue engineering research.

Original languageEnglish (US)
Pages (from-to)2877-2893
Number of pages17
JournalActa Biomaterialia
Volume10
Issue number7
DOIs
StatePublished - 2014

Fingerprint

Heart Valves
Tissue Engineering
Scaffolds (biology)
Tissue engineering
Heart Valve Diseases
Tissue
Engineering research
Cell proliferation
Cell Differentiation
Scaffolds
Cell Proliferation
Growth
Mechanical properties
Research

Keywords

  • Fiber
  • Heart valve
  • Hydrogel
  • Scaffold
  • Tissue engineering

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Medicine(all)

Cite this

Scaffolds for tissue engineering of cardiac valves. / Jana, Soumen; Tefft, B. J.; Spoon, D. B.; Simari, R. D.

In: Acta Biomaterialia, Vol. 10, No. 7, 2014, p. 2877-2893.

Research output: Contribution to journalArticle

Jana, Soumen ; Tefft, B. J. ; Spoon, D. B. ; Simari, R. D. / Scaffolds for tissue engineering of cardiac valves. In: Acta Biomaterialia. 2014 ; Vol. 10, No. 7. pp. 2877-2893.
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