Say when: Reversible control of gene expression in the mouse by lac

Heidi Scrable

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

In bacteria, coordinate expression of genes involved in lactose metabolism is regulated by the lac repressor and its DNA binding sequence, the lac operator. The lac operator-repressor complex can also be used to regulate gene expression in the laboratory mouse. In this review, I discuss the current state of murine trans-operons, and suggest ways this lac-based system might be used to build more advanced models of human diseases in the mouse.

Original languageEnglish (US)
Pages (from-to)109-119
Number of pages11
JournalSeminars in Cell and Developmental Biology
Volume13
Issue number2
DOIs
StatePublished - Jan 1 2002

Keywords

  • Animal model
  • Conditional
  • E. coli
  • Lac operator
  • Lac operon
  • Lac repressor
  • Transgenic

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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