TY - JOUR
T1 - Saturation time of exposure interval for cross-neutralization response to SARS-CoV-2
T2 - Implications for vaccine dose interval
AU - Miyamoto, Sho
AU - Kuroda, Yudai
AU - Kanno, Takayuki
AU - Ueno, Akira
AU - Shiwa-Sudo, Nozomi
AU - Iwata-Yoshikawa, Naoko
AU - Sakai, Yusuke
AU - Nagata, Noriyo
AU - Arashiro, Takeshi
AU - Ainai, Akira
AU - Moriyama, Saya
AU - Kishida, Noriko
AU - Watanabe, Shinji
AU - Nojima, Kiyoko
AU - Seki, Yohei
AU - Mizukami, Takuo
AU - Hasegawa, Hideki
AU - Ebihara, Hideki
AU - Fukushi, Shuetsu
AU - Takahashi, Yoshimasa
AU - Maeda, Ken
AU - Suzuki, Tadaki
N1 - Publisher Copyright:
© 2023 The Authors
PY - 2023/5/19
Y1 - 2023/5/19
N2 - Evaluating the serum cross-neutralization responses after breakthrough infection with various SARS-CoV-2 variants provides valuable insight for developing variant-proof COVID-19 booster vaccines. However, fairly comparing the impact of breakthrough infections with distinct epidemic timing on cross-neutralization responses, influenced by the exposure interval between vaccination and infection, is challenging. To compare the impact of pre-Omicron to Omicron breakthrough infection, we estimated the effects on cross-neutralizing responses by the exposure interval using Bayesian hierarchical modeling. The saturation time required to generate saturated cross-neutralization responses differed by variant, with variants more antigenically distant from the ancestral strain requiring longer intervals of 2–4 months. The breadths of saturated cross-neutralization responses to Omicron lineages were comparable in pre-Omicron and Omicron breakthrough infections. Our results highlight the importance of vaccine dosage intervals of 4 months or longer, regardless of the antigenicity of the exposed antigen, to maximize the breadth of serum cross-neutralization covering SARS-CoV-2 Omicron lineages.
AB - Evaluating the serum cross-neutralization responses after breakthrough infection with various SARS-CoV-2 variants provides valuable insight for developing variant-proof COVID-19 booster vaccines. However, fairly comparing the impact of breakthrough infections with distinct epidemic timing on cross-neutralization responses, influenced by the exposure interval between vaccination and infection, is challenging. To compare the impact of pre-Omicron to Omicron breakthrough infection, we estimated the effects on cross-neutralizing responses by the exposure interval using Bayesian hierarchical modeling. The saturation time required to generate saturated cross-neutralization responses differed by variant, with variants more antigenically distant from the ancestral strain requiring longer intervals of 2–4 months. The breadths of saturated cross-neutralization responses to Omicron lineages were comparable in pre-Omicron and Omicron breakthrough infections. Our results highlight the importance of vaccine dosage intervals of 4 months or longer, regardless of the antigenicity of the exposed antigen, to maximize the breadth of serum cross-neutralization covering SARS-CoV-2 Omicron lineages.
KW - Immune response
KW - Immune system
KW - Immunity
KW - Virology
UR - http://www.scopus.com/inward/record.url?scp=85153801674&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85153801674&partnerID=8YFLogxK
U2 - 10.1016/j.isci.2023.106694
DO - 10.1016/j.isci.2023.106694
M3 - Article
AN - SCOPUS:85153801674
SN - 2589-0042
VL - 26
JO - iScience
JF - iScience
IS - 5
M1 - 106694
ER -