Sarcomatoid Renal Cell Carcinoma: An Examination of Underlying Histologic Subtype and an Analysis of Associations with Patient Outcome

John C. Cheville, Christine M. Lohse, Horst Zincke, Amy L. Weaver, Bradley C. Leibovich, Igor Frank, Michael L. Blute

Research output: Contribution to journalReview article

267 Citations (Scopus)

Abstract

A sarcomatoid component can occur in all histologic subtypes of renal cell carcinoma (RCC) and indicates an aggressive tumor. We studied 2381 patients treated with radical nephrectomy for RCC between 1970 and 2000. A urologic pathologist reviewed the microscopic slides from all tumor specimens for the presence of a sarcomatoid component, defined as a RCC with any malignant spindle cell component. All tumors with a sarcomatoid component were classified as nuclear grade 4. A total of 120 (5.0%) patients had RCC with a sarcomatoid component, including 94 who died of RCC at a mean of 1.4 years following nephrectomy (median 8 months; range 44 days to 10 years). Cancer-specific survival rates at 2 and 5 years following nephrectomy were 33.3% and 14.5%, respectively. The presence of distant metastases at the radical nephrectomy and histologic tumor necrosis were significantly associated with death from RCC among patients with sarcomatoid RCC. Patients with clear cell (conventional) RCC and chromophobe RCC were more likely to have tumors with a sarcomatoid component (5.2% and 8.7%, respectively) compared with patients with papillary RCC (1.9%). The presence of a sarcomatoid component was significantly associated with death from RCC for all three subtypes (P < 0.001). Even among patients with grade 4 clear cell RCC, the presence of a sarcomatoid component was significantly associated with outcome, both univariately (risk ratio 1.59; P = 0.010) and after adjusting for TNM stage, tumor size, and histologic tumor necrosis (risk ratio 1.46; P = 0.037).

Original languageEnglish (US)
Pages (from-to)435-441
Number of pages7
JournalAmerican Journal of Surgical Pathology
Volume28
Issue number4
DOIs
StatePublished - Apr 2004

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Renal Cell Carcinoma
Nephrectomy
Neoplasms
Necrosis
Odds Ratio
Cellular Structures
Survival Rate
Neoplasm Metastasis

Keywords

  • Histologic subtype
  • Prognosis
  • Renal cell carcinoma
  • Sarcomatoid

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine

Cite this

Sarcomatoid Renal Cell Carcinoma : An Examination of Underlying Histologic Subtype and an Analysis of Associations with Patient Outcome. / Cheville, John C.; Lohse, Christine M.; Zincke, Horst; Weaver, Amy L.; Leibovich, Bradley C.; Frank, Igor; Blute, Michael L.

In: American Journal of Surgical Pathology, Vol. 28, No. 4, 04.2004, p. 435-441.

Research output: Contribution to journalReview article

Cheville, John C. ; Lohse, Christine M. ; Zincke, Horst ; Weaver, Amy L. ; Leibovich, Bradley C. ; Frank, Igor ; Blute, Michael L. / Sarcomatoid Renal Cell Carcinoma : An Examination of Underlying Histologic Subtype and an Analysis of Associations with Patient Outcome. In: American Journal of Surgical Pathology. 2004 ; Vol. 28, No. 4. pp. 435-441.
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