Sarcoidosis with major airway, vascular and nerve compromise

Hiroshi Sekiguchi, Jun Suzuki, James P. Utz

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

The present report describes a 60-year-old Caucasian woman who presented with progressive dyspnea, cough and wheeze. A computed tomography scan of the chest showed innumerable bilateral inflammatory pulmonary nodules with bronchovascular distribution and a mediastinal and hilar infiltrative process with calcified lymphadenopathy leading to narrowing of lobar bronchi and pulmonary arteries. An echocardiogram revealed pulmonary hypertension. Bronchoscopy showed left vocal cord paralysis and significant narrowing of the bilateral bronchi with mucosal thickening and multiple nodules. Transbronchial biopsy was compatible with sarcoidosis. Despite balloon angioplasty of the left lower lobe and pulmonary artery, and medical therapy with oral corticosteroids, her symptoms did not significantly improve. To the authors' knowledge, the present report describes the first case of pulmonary sarcoidosis resulting in major airway, vascular and nerve compromise due to compressive lymphadenopathy and suspected concurrent granulomatous infiltration. Its presentation mimicked idiopathic mediastinal fibrosis.

Original languageEnglish (US)
Pages (from-to)256-258
Number of pages3
JournalCanadian Respiratory Journal
Volume20
Issue number4
DOIs
StatePublished - 2013

Keywords

  • Airway narrowing
  • Mediastinal fibrosis
  • Pulmonary hypertension
  • Sarcoidosis
  • Vocal cord paralysis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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