Abstract
SALTIRE and RAAVE were the first two studies to evaluate the use of statin therapy for impeding calcific aortic valve disease (CAVD). This review presents the findings of low-density lipoprotein (LDL)-density-radius theory as tested using the combined results from the SALTIRE and RAAVE studies. Patients who received statin therapy had a greater degree of LDL cholesterol lowering, seen as the % change in LDL (47 vs 2%, p ≥ 0.012), which in itself was significantly associated with a lesser change in aortic valve area (AVA; p < 0.001 and R2 ≥ 0.27). The percent change in the AVA for the treated patients was 5% and 15% for the nontreated patients (p ≥ 0.579 and R2 ≥ 0.03). In summary, these published findings suggest that when applying the LDL-density-radius theory, which combines the cellular biology and the hemodynamics as defined by the continuity equation for AVA, there may be a role for lipid-lowering therapy in contemporary patients with calcific aortic valve disease (CAVD).
Original language | English (US) |
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Pages (from-to) | 355-367 |
Number of pages | 13 |
Journal | Expert Review of Cardiovascular Therapy |
Volume | 13 |
Issue number | 4 |
DOIs | |
State | Published - Apr 1 2015 |
Keywords
- aortic valve stenosis
- atherosclerosis
- calcification
- clinical trials
- hemodynamics
- statins
ASJC Scopus subject areas
- Internal Medicine
- Cardiology and Cardiovascular Medicine