Salt, water, and vasopressin in polycystic kidney disease

Vicente E. Torres

doi:10.1016/j.kint.2020.06.001

Salt, water, and vasopressin in polycystic kidney disease

Vicente E. Torres

Nephrology and Hypertension

Research output: Contribution to journal › Comment/debate › peer-review

1 Scopus citations

Abstract

Excessive salt intake and vasopressin may promote cyst growth in autosomal dominant polycystic kidney disease and glomerular filtration rate (GFR) decline in chronic kidney disease. Kramers et al. confirmed the effects of salt in a large autosomal dominant polycystic kidney disease cohort. Copeptin mediated 72% and 25% of the salt effects on GFR decline and kidney growth. Kidney growth did not significantly contribute to the copeptin-mediated salt effect on GFR. Differences in kidney growth and GFR decline trajectories and factors other than cyst growth contributing to GFR decline may explain the divergent effects.

Original language	English (US)
Pages (from-to)	831-834
Number of pages	4
Journal	Kidney international
Volume	98
Issue number	4
DOIs	https://doi.org/10.1016/j.kint.2020.06.001
State	Published - Oct 2020

ASJC Scopus subject areas

Nephrology

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title = "Salt, water, and vasopressin in polycystic kidney disease",

abstract = "Excessive salt intake and vasopressin may promote cyst growth in autosomal dominant polycystic kidney disease and glomerular filtration rate (GFR) decline in chronic kidney disease. Kramers et al. confirmed the effects of salt in a large autosomal dominant polycystic kidney disease cohort. Copeptin mediated 72% and 25% of the salt effects on GFR decline and kidney growth. Kidney growth did not significantly contribute to the copeptin-mediated salt effect on GFR. Differences in kidney growth and GFR decline trajectories and factors other than cyst growth contributing to GFR decline may explain the divergent effects.",

author = "Torres, {Vicente E.}",

note = "Publisher Copyright: {\textcopyright} 2020 International Society of Nephrology",

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PY - 2020/10

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N2 - Excessive salt intake and vasopressin may promote cyst growth in autosomal dominant polycystic kidney disease and glomerular filtration rate (GFR) decline in chronic kidney disease. Kramers et al. confirmed the effects of salt in a large autosomal dominant polycystic kidney disease cohort. Copeptin mediated 72% and 25% of the salt effects on GFR decline and kidney growth. Kidney growth did not significantly contribute to the copeptin-mediated salt effect on GFR. Differences in kidney growth and GFR decline trajectories and factors other than cyst growth contributing to GFR decline may explain the divergent effects.

AB - Excessive salt intake and vasopressin may promote cyst growth in autosomal dominant polycystic kidney disease and glomerular filtration rate (GFR) decline in chronic kidney disease. Kramers et al. confirmed the effects of salt in a large autosomal dominant polycystic kidney disease cohort. Copeptin mediated 72% and 25% of the salt effects on GFR decline and kidney growth. Kidney growth did not significantly contribute to the copeptin-mediated salt effect on GFR. Differences in kidney growth and GFR decline trajectories and factors other than cyst growth contributing to GFR decline may explain the divergent effects.

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Salt, water, and vasopressin in polycystic kidney disease

Abstract

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