Salt, water and nephron

Mechanisms of action and link to hypertension and chronic kidney disease

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Our knowledge on sodium and water homeostasis and regulation continues to evolve. A considerable amount of new information in this area has emerged in recent years. This review summarizes existing and new literature and discusses complex multi-organ effects of high-salt and low-water intake and role of arginine vasopressin in this process, as well as the potential clinical significance of non-osmotic sodium storage pool and rhythmicity of urine sodium excretion. It has become clear that sodium and water dysregulation can exert profound effects on kidney and vascular health, far greater than previously recognized. Maladaptation to a combined high-salt and low-water intake can be linked to the growing epidemic of hypertension and chronic kidney disease.

Original languageEnglish (US)
Pages (from-to)44-49
Number of pages6
JournalNephrology
Volume23
DOIs
StatePublished - Oct 1 2018

Fingerprint

Nephrons
Chronic Renal Insufficiency
Salts
Sodium
Hypertension
Water
Drinking
Arginine Vasopressin
Periodicity
Blood Vessels
Homeostasis
Urine
Kidney
Health

Keywords

  • arginine vasopressin (AVP)
  • chronic kidney disease (CKD)
  • hypertension
  • non-osmotic pool of sodium
  • salt and water regulation
  • skin

ASJC Scopus subject areas

  • Nephrology

Cite this

Salt, water and nephron : Mechanisms of action and link to hypertension and chronic kidney disease. / Qian, Qi.

In: Nephrology, Vol. 23, 01.10.2018, p. 44-49.

Research output: Contribution to journalReview article

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