Salivary gland-type lung carcinomas: An EGFR immunohistochemical, molecular genetic, and mutational analysis study

Ricardo S. Macarenco, Timothy S. Uphoff, Heather Flynn Gilmer, Robert Brian Jenkins, Stephen N Thibodeau, Jean E. Lewis, Julian R Molina, Ping Yang, Marie Christine Aubry

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Salivary gland-type lung carcinomas are uncommon neoplasms of the lung, the two most common being adenoid cystic carcinoma and mucoepidermoid carcinoma. Although they usually have an indolent behavior, adenoid cystic carcinomas can be more aggressive, with 5-year survival as low as 55%. Unfortunately, these tumors do not respond well to chemotherapy. In contrast to the most common subtypes of lung carcinomas, epidermal growth factor receptor studies have not been carried out in this group of tumors. Herein we report a series of 24 cases (12 adenoid cystic and 12 mucoepidermoid carcinomas) tested for epidermal growth factor receptor protein expression, epidermal growth factor receptor gene copy gains, and epidermal growth factor receptor gene mutational status, through immunohistochemistry, fluorescence in situ hybridization, and sequencing of the exons 18-21, respectively. Overall, 91 and 92% of the adenoid cystic carcinomas and mucoepidermoid carcinomas expressed epidermal growth factor receptor protein. Chromosome 7 polysomy occurred in 25% of the cases (four adenoid cystic carcinomas and two mucoepidermoid carcinomas). No epidermal growth factor receptor gene amplification was detected and no mutation was found in exons 18-21 of the epidermal growth factor receptor gene. Immunoexpression of epidermal growth factor receptor in salivary gland-type lung carcinomas is not related to epidermal growth factor receptor gene copy number or mutational status.

Original languageEnglish (US)
Pages (from-to)1168-1175
Number of pages8
JournalModern Pathology
Volume21
Issue number9
DOIs
StatePublished - Sep 2008

Fingerprint

erbB-1 Genes
Mucoepidermoid Carcinoma
Salivary Glands
Adenoid Cystic Carcinoma
Molecular Biology
Epidermal Growth Factor Receptor
Carcinoma
Lung
Exons
Adenoids
Chromosomes, Human, Pair 7
Gene Dosage
Gene Amplification
Fluorescence In Situ Hybridization
Lung Neoplasms
Neoplasms
Proteins
Immunohistochemistry
Drug Therapy
Mutation

Keywords

  • Adenoid cystic carcinoma
  • Epidermal growth factor receptor
  • FISH
  • Immunohistochemistry
  • Mucoepidermoid carcinoma
  • Salivary gland-type lung carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Salivary gland-type lung carcinomas : An EGFR immunohistochemical, molecular genetic, and mutational analysis study. / Macarenco, Ricardo S.; Uphoff, Timothy S.; Gilmer, Heather Flynn; Jenkins, Robert Brian; Thibodeau, Stephen N; Lewis, Jean E.; Molina, Julian R; Yang, Ping; Aubry, Marie Christine.

In: Modern Pathology, Vol. 21, No. 9, 09.2008, p. 1168-1175.

Research output: Contribution to journalArticle

Macarenco, Ricardo S. ; Uphoff, Timothy S. ; Gilmer, Heather Flynn ; Jenkins, Robert Brian ; Thibodeau, Stephen N ; Lewis, Jean E. ; Molina, Julian R ; Yang, Ping ; Aubry, Marie Christine. / Salivary gland-type lung carcinomas : An EGFR immunohistochemical, molecular genetic, and mutational analysis study. In: Modern Pathology. 2008 ; Vol. 21, No. 9. pp. 1168-1175.
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