TY - JOUR
T1 - Safety of Infliximab and Other Biologic Agents in the Inflammatory Bowel Diseases
AU - Reddy, Jagadeshwar G.
AU - Loftus, Edward V.
PY - 2006/12/1
Y1 - 2006/12/1
N2 - In many ways, infliximab has drastically altered expectations for medical therapy in IBD, and it is expected that adalimumab and certolizumab pegol will ultimately have a similar role. Patients initiating such therapy should be made cognizant of the potential risks of serious infection including opportunistic ones, such as TB and histoplasmosis; demyelinating disorders; CHF; and lymphoma. Proper selection of candidates for anti-TNF-α therapy is critical in maintaining a proper benefit-to-risk ratio.
AB - In many ways, infliximab has drastically altered expectations for medical therapy in IBD, and it is expected that adalimumab and certolizumab pegol will ultimately have a similar role. Patients initiating such therapy should be made cognizant of the potential risks of serious infection including opportunistic ones, such as TB and histoplasmosis; demyelinating disorders; CHF; and lymphoma. Proper selection of candidates for anti-TNF-α therapy is critical in maintaining a proper benefit-to-risk ratio.
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U2 - 10.1016/j.gtc.2006.09.008
DO - 10.1016/j.gtc.2006.09.008
M3 - Review article
C2 - 17129816
AN - SCOPUS:33751334334
VL - 35
SP - 837
EP - 855
JO - Gastroenterology Clinics of North America
JF - Gastroenterology Clinics of North America
SN - 0889-8553
IS - 4
ER -