Safety factor for neuromuscular transmission at type-identified diaphragm fibers

Leonid G. Ermilov; Carlos B. Mantilla; Katharine L. Rowley; Gary C. Sieck

doi:10.1002/mus.20751

Safety factor for neuromuscular transmission at type-identified diaphragm fibers

Leonid G. Ermilov, Carlos B. Mantilla, Katharine L. Rowley, Gary C. Sieck

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

The safety factor (SF) for neuromuscular transmission varies across limb muscles of different fiber-type composition. Using intracellular recordings in rat diaphragm fibers, we found that SF varies across muscle fiber types (even within a single muscle), being larger for type IIx or IIb fibers than for type I or IIa fibers. Fiber-type differences in activation history or mechanical load may contribute to differences in SF and are important determinants of neuromuscular plasticity.

Original language	English (US)
Pages (from-to)	800-803
Number of pages	4
Journal	Muscle and Nerve
Volume	35
Issue number	6
DOIs	https://doi.org/10.1002/mus.20751
State	Published - Jun 2007

Keywords

Motor unit
Phrenic motoneurons
Plasticity
Synaptic efficacy
Ventilation

ASJC Scopus subject areas

Physiology
Clinical Neurology
Cellular and Molecular Neuroscience
Physiology (medical)

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10.1002/mus.20751

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AU - Mantilla, Carlos B.

AU - Rowley, Katharine L.

AU - Sieck, Gary C.

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AB - The safety factor (SF) for neuromuscular transmission varies across limb muscles of different fiber-type composition. Using intracellular recordings in rat diaphragm fibers, we found that SF varies across muscle fiber types (even within a single muscle), being larger for type IIx or IIb fibers than for type I or IIa fibers. Fiber-type differences in activation history or mechanical load may contribute to differences in SF and are important determinants of neuromuscular plasticity.

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KW - Phrenic motoneurons

KW - Plasticity

KW - Synaptic efficacy

KW - Ventilation

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Safety factor for neuromuscular transmission at type-identified diaphragm fibers

Abstract

Keywords

ASJC Scopus subject areas

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