Safety and technical success of methylene blue dye for lymphatic mapping in breast cancer

Shaheen Zakaria, Tanya L. Hoskin, Amy C Degnim

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Background: We aimed to evaluate the safety and efficacy of methylene blue dye (MBD) for sentinel lymph node (SLN) mapping in breast cancer. Methods: A total of 398 patients undergoing 401 SLN biopsy procedures with MBD were retrospectively reviewed and divided into 3 groups based on dye concentration and location of dye injection. Technical success and complication rates were compared. Results: Overall technical success of SLN biopsy was 99.7%. Technical success of SLN mapping with MBD was lowest in the group receiving full strength dye in a peritumoral location (74%) and highest in the group that received very dilute MBD (1.25 mg/mL) in the subareolar location (92%, P = .004). The complication rate was highest in the first group (21%) and lowest in the latter (2%, P = .0003). Conclusions: Dilute MBD (1.25 mg/mL) successfully maps SLNs with very few complications.

Original languageEnglish (US)
Pages (from-to)228-233
Number of pages6
JournalAmerican Journal of Surgery
Volume196
Issue number2
DOIs
StatePublished - Aug 2008

Fingerprint

Methylene Blue
Coloring Agents
Breast Neoplasms
Safety
Sentinel Lymph Node Biopsy
Injections

Keywords

  • Allergic reaction
  • Anaphylaxis
  • Breast neoplasms
  • Isosulfan blue dye
  • Methylene blue dye
  • Sentinel lymph node biopsy
  • Skin necrosis

ASJC Scopus subject areas

  • Surgery

Cite this

Safety and technical success of methylene blue dye for lymphatic mapping in breast cancer. / Zakaria, Shaheen; Hoskin, Tanya L.; Degnim, Amy C.

In: American Journal of Surgery, Vol. 196, No. 2, 08.2008, p. 228-233.

Research output: Contribution to journalArticle

@article{3c5df3e0fed943bca8f5e926c5f17f4a,
title = "Safety and technical success of methylene blue dye for lymphatic mapping in breast cancer",
abstract = "Background: We aimed to evaluate the safety and efficacy of methylene blue dye (MBD) for sentinel lymph node (SLN) mapping in breast cancer. Methods: A total of 398 patients undergoing 401 SLN biopsy procedures with MBD were retrospectively reviewed and divided into 3 groups based on dye concentration and location of dye injection. Technical success and complication rates were compared. Results: Overall technical success of SLN biopsy was 99.7{\%}. Technical success of SLN mapping with MBD was lowest in the group receiving full strength dye in a peritumoral location (74{\%}) and highest in the group that received very dilute MBD (1.25 mg/mL) in the subareolar location (92{\%}, P = .004). The complication rate was highest in the first group (21{\%}) and lowest in the latter (2{\%}, P = .0003). Conclusions: Dilute MBD (1.25 mg/mL) successfully maps SLNs with very few complications.",
keywords = "Allergic reaction, Anaphylaxis, Breast neoplasms, Isosulfan blue dye, Methylene blue dye, Sentinel lymph node biopsy, Skin necrosis",
author = "Shaheen Zakaria and Hoskin, {Tanya L.} and Degnim, {Amy C}",
year = "2008",
month = "8",
doi = "10.1016/j.amjsurg.2007.08.060",
language = "English (US)",
volume = "196",
pages = "228--233",
journal = "American Journal of Surgery",
issn = "0002-9610",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - Safety and technical success of methylene blue dye for lymphatic mapping in breast cancer

AU - Zakaria, Shaheen

AU - Hoskin, Tanya L.

AU - Degnim, Amy C

PY - 2008/8

Y1 - 2008/8

N2 - Background: We aimed to evaluate the safety and efficacy of methylene blue dye (MBD) for sentinel lymph node (SLN) mapping in breast cancer. Methods: A total of 398 patients undergoing 401 SLN biopsy procedures with MBD were retrospectively reviewed and divided into 3 groups based on dye concentration and location of dye injection. Technical success and complication rates were compared. Results: Overall technical success of SLN biopsy was 99.7%. Technical success of SLN mapping with MBD was lowest in the group receiving full strength dye in a peritumoral location (74%) and highest in the group that received very dilute MBD (1.25 mg/mL) in the subareolar location (92%, P = .004). The complication rate was highest in the first group (21%) and lowest in the latter (2%, P = .0003). Conclusions: Dilute MBD (1.25 mg/mL) successfully maps SLNs with very few complications.

AB - Background: We aimed to evaluate the safety and efficacy of methylene blue dye (MBD) for sentinel lymph node (SLN) mapping in breast cancer. Methods: A total of 398 patients undergoing 401 SLN biopsy procedures with MBD were retrospectively reviewed and divided into 3 groups based on dye concentration and location of dye injection. Technical success and complication rates were compared. Results: Overall technical success of SLN biopsy was 99.7%. Technical success of SLN mapping with MBD was lowest in the group receiving full strength dye in a peritumoral location (74%) and highest in the group that received very dilute MBD (1.25 mg/mL) in the subareolar location (92%, P = .004). The complication rate was highest in the first group (21%) and lowest in the latter (2%, P = .0003). Conclusions: Dilute MBD (1.25 mg/mL) successfully maps SLNs with very few complications.

KW - Allergic reaction

KW - Anaphylaxis

KW - Breast neoplasms

KW - Isosulfan blue dye

KW - Methylene blue dye

KW - Sentinel lymph node biopsy

KW - Skin necrosis

UR - http://www.scopus.com/inward/record.url?scp=47049088535&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=47049088535&partnerID=8YFLogxK

U2 - 10.1016/j.amjsurg.2007.08.060

DO - 10.1016/j.amjsurg.2007.08.060

M3 - Article

C2 - 18367146

AN - SCOPUS:47049088535

VL - 196

SP - 228

EP - 233

JO - American Journal of Surgery

JF - American Journal of Surgery

SN - 0002-9610

IS - 2

ER -