Safety and efficacy of valproate and carbamazepine in the treatment of complex partial seizures

E. L. So, C. W. Lai, J. Pellock, J. Mashman, A. Brugger

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

We conducted a randomized, double-blind study of 33 patients comparing valproate (VPA) and carbamazepine (CBZ) in the treatment of complex partial seizures (CPS). Patients between the ages of 10 and 70, who had experienced at least two CPS and were previously untreated or insufficiently treated, were considered for the study. Results showed that 64% of the patients who received VPA and 64% of the patients who received CBZ were free of CPS during the 24-week maintenance period. The only significant differences in adverse events were weight gain and tremor seen in patients who received VPA. This study showed that VPA monotherapy is as effective as CBZ monotherapy in the treatment of CPS.

Original languageEnglish (US)
Pages (from-to)149-152
Number of pages4
JournalJournal of Epilepsy
Volume5
Issue number3
DOIs
StatePublished - 1992

Keywords

  • Carbamazepine
  • Complex partial seizures
  • Drug comparison
  • Monotherapy
  • Valproate

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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