Safety and efficacy of valproate and carbamazepine in the treatment of complex partial seizures

E. L. So, C. W. Lai, J. Pellock, J. Mashman, A. Brugger

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

We conducted a randomized, double-blind study of 33 patients comparing valproate (VPA) and carbamazepine (CBZ) in the treatment of complex partial seizures (CPS). Patients between the ages of 10 and 70, who had experienced at least two CPS and were previously untreated or insufficiently treated, were considered for the study. Results showed that 64% of the patients who received VPA and 64% of the patients who received CBZ were free of CPS during the 24-week maintenance period. The only significant differences in adverse events were weight gain and tremor seen in patients who received VPA. This study showed that VPA monotherapy is as effective as CBZ monotherapy in the treatment of CPS.

Original languageEnglish (US)
Pages (from-to)149-152
Number of pages4
JournalJournal of Epilepsy
Volume5
Issue number3
DOIs
StatePublished - 1992
Externally publishedYes

Fingerprint

Carbamazepine
Valproic Acid
Seizures
Safety
Therapeutics
Tremor
Double-Blind Method
Weight Gain
Maintenance

Keywords

  • Carbamazepine
  • Complex partial seizures
  • Drug comparison
  • Monotherapy
  • Valproate

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Safety and efficacy of valproate and carbamazepine in the treatment of complex partial seizures. / So, E. L.; Lai, C. W.; Pellock, J.; Mashman, J.; Brugger, A.

In: Journal of Epilepsy, Vol. 5, No. 3, 1992, p. 149-152.

Research output: Contribution to journalArticle

So, E. L. ; Lai, C. W. ; Pellock, J. ; Mashman, J. ; Brugger, A. / Safety and efficacy of valproate and carbamazepine in the treatment of complex partial seizures. In: Journal of Epilepsy. 1992 ; Vol. 5, No. 3. pp. 149-152.
@article{0d378c021996477ab29d58027c35236f,
title = "Safety and efficacy of valproate and carbamazepine in the treatment of complex partial seizures",
abstract = "We conducted a randomized, double-blind study of 33 patients comparing valproate (VPA) and carbamazepine (CBZ) in the treatment of complex partial seizures (CPS). Patients between the ages of 10 and 70, who had experienced at least two CPS and were previously untreated or insufficiently treated, were considered for the study. Results showed that 64{\%} of the patients who received VPA and 64{\%} of the patients who received CBZ were free of CPS during the 24-week maintenance period. The only significant differences in adverse events were weight gain and tremor seen in patients who received VPA. This study showed that VPA monotherapy is as effective as CBZ monotherapy in the treatment of CPS.",
keywords = "Carbamazepine, Complex partial seizures, Drug comparison, Monotherapy, Valproate",
author = "So, {E. L.} and Lai, {C. W.} and J. Pellock and J. Mashman and A. Brugger",
year = "1992",
doi = "10.1016/S0896-6974(05)80133-1",
language = "English (US)",
volume = "5",
pages = "149--152",
journal = "Epilepsy Research",
issn = "0920-1211",
publisher = "Elsevier",
number = "3",

}

TY - JOUR

T1 - Safety and efficacy of valproate and carbamazepine in the treatment of complex partial seizures

AU - So, E. L.

AU - Lai, C. W.

AU - Pellock, J.

AU - Mashman, J.

AU - Brugger, A.

PY - 1992

Y1 - 1992

N2 - We conducted a randomized, double-blind study of 33 patients comparing valproate (VPA) and carbamazepine (CBZ) in the treatment of complex partial seizures (CPS). Patients between the ages of 10 and 70, who had experienced at least two CPS and were previously untreated or insufficiently treated, were considered for the study. Results showed that 64% of the patients who received VPA and 64% of the patients who received CBZ were free of CPS during the 24-week maintenance period. The only significant differences in adverse events were weight gain and tremor seen in patients who received VPA. This study showed that VPA monotherapy is as effective as CBZ monotherapy in the treatment of CPS.

AB - We conducted a randomized, double-blind study of 33 patients comparing valproate (VPA) and carbamazepine (CBZ) in the treatment of complex partial seizures (CPS). Patients between the ages of 10 and 70, who had experienced at least two CPS and were previously untreated or insufficiently treated, were considered for the study. Results showed that 64% of the patients who received VPA and 64% of the patients who received CBZ were free of CPS during the 24-week maintenance period. The only significant differences in adverse events were weight gain and tremor seen in patients who received VPA. This study showed that VPA monotherapy is as effective as CBZ monotherapy in the treatment of CPS.

KW - Carbamazepine

KW - Complex partial seizures

KW - Drug comparison

KW - Monotherapy

KW - Valproate

UR - http://www.scopus.com/inward/record.url?scp=0026646507&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026646507&partnerID=8YFLogxK

U2 - 10.1016/S0896-6974(05)80133-1

DO - 10.1016/S0896-6974(05)80133-1

M3 - Article

AN - SCOPUS:0026646507

VL - 5

SP - 149

EP - 152

JO - Epilepsy Research

JF - Epilepsy Research

SN - 0920-1211

IS - 3

ER -