Safety and efficacy of intravenous contrast imaging in pediatric echocardiography

C. J. McMahon, N. A. Ayres, L. I. Bezold, M. B. Lewin, M. Alonzo, C. A. Altman, J. P. Kovalchin, Benjamin W. Eidem, R. H. Pignatelli

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

This study was performed to determine the safety and efficacy of intravenous contrast echocardiography in children attending a tertiary cardiac center. This was a prospective study to evaluate the use of Optison contrast agent in children with severely limited transthoracic echocardiographic windows. Twenty children (median age, 15 years; range, 9-18) underwent fundamental imaging (FI), harmonic imaging (HI), and HI with intravenous contrast (Optison FS-069). Endocardial border delineation was determined based on a visual qualitative scoring system (0, none: 4, excellent). Endocardial border definition was significantly improved in all patients using contrast echocardiography (FI vs Optison, p < 0.001 for each). Improved border definition was most dramatic in the apical and left ventricular (LV) free wall regions. Left ventricular ejection fraction (LVEF) was measurable in 20 patients (100%) using contrast compared to 11 (55%) with FI or HI (p < 0.05). The echocardiographic diagnosis was correctly delineated in 1 patient with a severely dyskinetic LV segment only with use of intravenous contrast and HI. No patients suffered adverse hemodynamic effects, changes in taste, or flushing episodes. Three patients experienced transient headaches. Intravenous contrast echocardiography offers an additional tool in evaluating children with very poor transthoracic echocardiographic windows. Such a strategy increases diagnostic accuracy and allows accurate LVEF determination. Adverse hemodynamic effects related to intravenous contrast are exceedingly rare.

Original languageEnglish (US)
Pages (from-to)413-417
Number of pages5
JournalPediatric Cardiology
Volume26
Issue number4
DOIs
StatePublished - Aug 2005
Externally publishedYes

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Echocardiography
Pediatrics
Safety
Stroke Volume
Hemodynamics
Contrast Media
Headache
Prospective Studies
FS 069

Keywords

  • Congenital heart disease
  • Contrast echocardiography

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pediatrics, Perinatology, and Child Health

Cite this

McMahon, C. J., Ayres, N. A., Bezold, L. I., Lewin, M. B., Alonzo, M., Altman, C. A., ... Pignatelli, R. H. (2005). Safety and efficacy of intravenous contrast imaging in pediatric echocardiography. Pediatric Cardiology, 26(4), 413-417. https://doi.org/10.1007/s00246-004-0795-1

Safety and efficacy of intravenous contrast imaging in pediatric echocardiography. / McMahon, C. J.; Ayres, N. A.; Bezold, L. I.; Lewin, M. B.; Alonzo, M.; Altman, C. A.; Kovalchin, J. P.; Eidem, Benjamin W.; Pignatelli, R. H.

In: Pediatric Cardiology, Vol. 26, No. 4, 08.2005, p. 413-417.

Research output: Contribution to journalArticle

McMahon, CJ, Ayres, NA, Bezold, LI, Lewin, MB, Alonzo, M, Altman, CA, Kovalchin, JP, Eidem, BW & Pignatelli, RH 2005, 'Safety and efficacy of intravenous contrast imaging in pediatric echocardiography', Pediatric Cardiology, vol. 26, no. 4, pp. 413-417. https://doi.org/10.1007/s00246-004-0795-1
McMahon CJ, Ayres NA, Bezold LI, Lewin MB, Alonzo M, Altman CA et al. Safety and efficacy of intravenous contrast imaging in pediatric echocardiography. Pediatric Cardiology. 2005 Aug;26(4):413-417. https://doi.org/10.1007/s00246-004-0795-1
McMahon, C. J. ; Ayres, N. A. ; Bezold, L. I. ; Lewin, M. B. ; Alonzo, M. ; Altman, C. A. ; Kovalchin, J. P. ; Eidem, Benjamin W. ; Pignatelli, R. H. / Safety and efficacy of intravenous contrast imaging in pediatric echocardiography. In: Pediatric Cardiology. 2005 ; Vol. 26, No. 4. pp. 413-417.
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