Safety and Effectiveness of Topical Anesthetics in Corneal Abrasions: Systematic Review and Meta-Analysis

Henrique A. Puls, Daniel Cabrera, Mohammad H Murad, Patricia J. Erwin, Fernanda Bellolio

Research output: Contribution to journalArticle

8 Scopus citations


Background Topical anesthetics are used in the emergency department (ED) to relieve eye pain and allow eye examinations in patients with corneal abrasions. There is concern for delayed corneal healing, which is associated with the long-term use of topical anesthetics, so outpatient use is not recommended. Objectives We sought to systematically study the effectiveness and complications associated with the short-term use of topical anesthetics (&72 hours) in the management of patients presenting to EDs with corneal abrasions. Methods Four electronic databases were searched from inception of the database until April 2014. We included studies of patients >16 years of age who were using topical anesthetics for ;

Original languageEnglish (US)
Pages (from-to)816-824
Number of pages9
JournalJournal of Emergency Medicine
Issue number5
StatePublished - Nov 1 2015



  • adverse effects
  • complications
  • corneal abrasions
  • corneal healing
  • effectiveness
  • emergency department
  • eye pain
  • meta-analysis
  • pain scores
  • persistent symptoms
  • satisfaction
  • systematic review
  • topical anesthetics

ASJC Scopus subject areas

  • Emergency Medicine

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