Safe Use of Antirheumatic Agents in Patients with Comorbidities

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3 Citations (Scopus)

Abstract

The burden of comorbid diseases is high among patients with rheumatoid arthritis (RA). These are often systemic manifestations of RA but may be chronic conditions that predate or develop post-RA diagnosis. Increased mortality in RA is predominantly from nonarticular causes. The expanded armamentarium of disease-modifying drugs and biologics available has revolutionized management of articular disease but has made safe treatment of RA more complex. Drug-induced organ injury and side effects need to be kept in mind when initiating or modifying therapy.

Original languageEnglish (US)
Pages (from-to)771-793
Number of pages23
JournalRheumatic Disease Clinics of North America
Volume38
Issue number4
DOIs
StatePublished - Nov 2012

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Antirheumatic Agents
Comorbidity
Rheumatoid Arthritis
Disease Management
Prednisolone
Biological Products
Pharmaceutical Preparations
Joints
Mortality
Wounds and Injuries
Therapeutics

Keywords

  • Adverse drug effects
  • Comorbidties
  • Disease-modifying antirheumatic drugs
  • Rheumatoid arthritis
  • Treatment

ASJC Scopus subject areas

  • Rheumatology

Cite this

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abstract = "The burden of comorbid diseases is high among patients with rheumatoid arthritis (RA). These are often systemic manifestations of RA but may be chronic conditions that predate or develop post-RA diagnosis. Increased mortality in RA is predominantly from nonarticular causes. The expanded armamentarium of disease-modifying drugs and biologics available has revolutionized management of articular disease but has made safe treatment of RA more complex. Drug-induced organ injury and side effects need to be kept in mind when initiating or modifying therapy.",
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