S-adenosyl methionine and DNA methyltransferase-1 mRNA overexpression in psychosis

Alessandro Guidotti, William Ruzicka, Dennis R. Grayson, Marin Veldic, Graziano Pinna, John M. Davis, Erminio Costa

Research output: Contribution to journalArticle

82 Scopus citations

Abstract

Prefrontal cortex (Brodmann's area 9) levels of the methyl donor S-adenosyl methionine were increased by about two-fold in schizophrenia and bipolar disorder patients, but not in unipolar depressed patients compared with nonpsychiatric subjects from the Stanley Foundation Neuropathology Consortium (Bethesda, Maryland, USA). Neither age, brain weight and pH, hemisphere, post-mortem interval, disease onset/duration, nor cumulative dose of fluphenazine affected S-adenosyl methionine content. In schizophrenia and bipolar disorder patients, the increase of S-adenosyl methionine is associated with an overexpression of DNA methyltransferase-1 mRNA in Brodmann's area 9 GABAergic neurons. Hence, the increased expression of S-adenosyl methionine and DNA methyltransferase-1 may contribute to promoter cytosine 5-methylation and to downregulation of the expression of mRNAs encoding for reelin and GAD67 in cortical GABAergic neurons of schizhophrenia and bipolar disorder patients.

Original languageEnglish (US)
Pages (from-to)57-60
Number of pages4
JournalNeuroReport
Volume18
Issue number1
DOIs
StatePublished - Jan 1 2007

Keywords

  • Cytosine methylation
  • Epigenetic
  • GABAergic neurons
  • Homocysteine
  • Methionine
  • Schizophrenia

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'S-adenosyl methionine and DNA methyltransferase-1 mRNA overexpression in psychosis'. Together they form a unique fingerprint.

  • Cite this

    Guidotti, A., Ruzicka, W., Grayson, D. R., Veldic, M., Pinna, G., Davis, J. M., & Costa, E. (2007). S-adenosyl methionine and DNA methyltransferase-1 mRNA overexpression in psychosis. NeuroReport, 18(1), 57-60. https://doi.org/10.1097/WNR.0b013e32800fefd7