Sézary syndrome and mycosis fungoides: An overview, including the role of immunophenotyping

Melissa P. Pulitzer, Pedro Horna, Julia Almeida

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

This review discusses the definition and major categories of cutaneous T-cell lymphoma, Sézary syndrome and mycosis fungoides, and the role of immunophenotyping in their diagnosis. The following key points are raised: (a) Sézary syndrome and mycosis fungoides cells most often have a characteristic CD3+ CD4+ CD7− and/or CD26− immunophenotype. (b) This immunophenotype is not specific, but can assist in the distinction from non-neoplastic T cells and other subtypes of mature T-cell neoplasm. (c) However, small subsets of normal and reactive T-cells can have an overlapping immunophenotype, and can be distinguished by evaluating for additional changes in antigen expression.

Original languageEnglish (US)
Pages (from-to)132-138
Number of pages7
JournalCytometry Part B - Clinical Cytometry
Volume100
Issue number2
DOIs
StatePublished - Mar 2021

Keywords

  • Sézary syndrome
  • T-cell
  • flow cytometry
  • lymphocyte
  • mycosis fungoides

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Cell Biology

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