TY - JOUR
T1 - Sézary syndrome and mycosis fungoides
T2 - An overview, including the role of immunophenotyping
AU - Pulitzer, Melissa P.
AU - Horna, Pedro
AU - Almeida, Julia
N1 - Publisher Copyright:
© 2020 International Clinical Cytometry Society
PY - 2021/3
Y1 - 2021/3
N2 - This review discusses the definition and major categories of cutaneous T-cell lymphoma, Sézary syndrome and mycosis fungoides, and the role of immunophenotyping in their diagnosis. The following key points are raised: (a) Sézary syndrome and mycosis fungoides cells most often have a characteristic CD3+ CD4+ CD7− and/or CD26− immunophenotype. (b) This immunophenotype is not specific, but can assist in the distinction from non-neoplastic T cells and other subtypes of mature T-cell neoplasm. (c) However, small subsets of normal and reactive T-cells can have an overlapping immunophenotype, and can be distinguished by evaluating for additional changes in antigen expression.
AB - This review discusses the definition and major categories of cutaneous T-cell lymphoma, Sézary syndrome and mycosis fungoides, and the role of immunophenotyping in their diagnosis. The following key points are raised: (a) Sézary syndrome and mycosis fungoides cells most often have a characteristic CD3+ CD4+ CD7− and/or CD26− immunophenotype. (b) This immunophenotype is not specific, but can assist in the distinction from non-neoplastic T cells and other subtypes of mature T-cell neoplasm. (c) However, small subsets of normal and reactive T-cells can have an overlapping immunophenotype, and can be distinguished by evaluating for additional changes in antigen expression.
KW - Sézary syndrome
KW - T-cell
KW - flow cytometry
KW - lymphocyte
KW - mycosis fungoides
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U2 - 10.1002/cyto.b.21888
DO - 10.1002/cyto.b.21888
M3 - Review article
C2 - 32516521
AN - SCOPUS:85086153205
SN - 1552-4949
VL - 100
SP - 132
EP - 138
JO - Cytometry Part B - Clinical Cytometry
JF - Cytometry Part B - Clinical Cytometry
IS - 2
ER -