Runx2 protein represses axin2 expression in osteoblasts and is required for craniosynostosis in axin2-deficient mice

Meghan E. McGee-Lawrence, Xiaodong Li, Krista L. Bledsoe, Hai Wu, John R. Hawse, Malayannan Subramaniam, David F. Razidlo, Bridget A. Stensgard, Gary S. Stein, Andre J. Van Wijnen, Jane B. Lian, Wei Hsu, Jennifer J. Westendorf

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Background: Runx2 and Axin2 are required for proper skeletal development. Results: Runx2 and Hdac3 repress Axin2 transcription in osteoblasts. Runx2 insufficiency prevents craniosynostosis in Axin2- deficient mice. Conclusion: A Runx2-Axin2 regulatory mechanism controls the pace of calvarial bone formation. Significance: The molecular and functional interplay between Runx2 and Axin2 controls the rate of cranial suture closure. Similar interactions may occur during skeletal development and carcinogenesis.

Original languageEnglish (US)
Pages (from-to)5291-5302
Number of pages12
JournalJournal of Biological Chemistry
Volume288
Issue number8
DOIs
StatePublished - Feb 22 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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    McGee-Lawrence, M. E., Li, X., Bledsoe, K. L., Wu, H., Hawse, J. R., Subramaniam, M., Razidlo, D. F., Stensgard, B. A., Stein, G. S., Van Wijnen, A. J., Lian, J. B., Hsu, W., & Westendorf, J. J. (2013). Runx2 protein represses axin2 expression in osteoblasts and is required for craniosynostosis in axin2-deficient mice. Journal of Biological Chemistry, 288(8), 5291-5302. https://doi.org/10.1074/jbc.M112.414995