Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression

Gary S. Stein, Jane B. Lian, Andre J. Van Wijnen, Janet L. Stein, Martin Montecino, Amjad Javed, Sayyed K. Zaidi, Daniel W. Young, Je Yong Choi, Shirwin M. Pockwinse

Research output: Contribution to journalReview article

356 Scopus citations

Abstract

We present an overview of Runx involvement in regulatory mechanisms that are requisite for fidelity of bone cell growth and differentiation, as well as for skeletal homeostasis and the structural and functional integrity of skeletal tissue. Runx-mediated control is addressed from the perspective of support for biological parameters of skeletal gene expression. We review recent findings that are consistent with an active role for Runx proteins as scaffolds for integration, organization and combinatorial assembly of nucleic acids and regulatory factors within the three-dimensional context of nuclear architecture.

Original languageEnglish (US)
Pages (from-to)4315-4329
Number of pages15
JournalOncogene
Volume23
Issue number24
DOIs
StatePublished - May 24 2004

Keywords

  • Chromatin modifications
  • Gene expression
  • Nuclear architecture
  • Osteoblast
  • Runx/AML/Cbfa

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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    Stein, G. S., Lian, J. B., Van Wijnen, A. J., Stein, J. L., Montecino, M., Javed, A., Zaidi, S. K., Young, D. W., Choi, J. Y., & Pockwinse, S. M. (2004). Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression. Oncogene, 23(24), 4315-4329. https://doi.org/10.1038/sj.onc.1207676