Routine erythrocyte measurements in diagnosis of iron deficiency anemia and thalassemia minor

G. G. Klee, V. F. Fairbanks, R. V. Pierre, M. B. O'Sullivan

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47 Scopus citations

Abstract

A study was made of the routine electronic measurements of erythrocyte size and hemoglobin concentration in blood samples from 122 patients with decreased transferrin saturation and 66 patients with elevated levels of hemoglobin A2 or F. The medical histories of these patients were reviewed to identify 52 cases of uncomplicated iron deficiency anemia and 39 cases of uncomplicated thalassemia minor. Four decision functions were compared for separating these two disorders. The functions evaluated were: D.F'. = MCV - [5 x Hb] RBC; ratio MCV/RBC; ratio MCH/RBC; and RBC. The rules performed better in the uncomplicated cases than in the routine laboratory defined cases. Only minor differences in the performances of the various decision functions were observed. None was sufficiently accurate for final diagnosis, but they should have value in screening patients and in determining which additional tests should be considered.

Original languageEnglish (US)
Pages (from-to)870-877
Number of pages8
JournalAmerican Journal of Clinical Pathology
Volume66
Issue number5
StatePublished - 1976

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ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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Klee, G. G., Fairbanks, V. F., Pierre, R. V., & O'Sullivan, M. B. (1976). Routine erythrocyte measurements in diagnosis of iron deficiency anemia and thalassemia minor. American Journal of Clinical Pathology, 66(5), 870-877.