Routine erythrocyte measurements in diagnosis of iron deficiency anemia and thalassemia minor

G. G. Klee; V. F. Fairbanks; R. V. Pierre; M. B. O'Sullivan

doi:10.1093/ajcp/66.5.870

Routine erythrocyte measurements in diagnosis of iron deficiency anemia and thalassemia minor

G. G. Klee, V. F. Fairbanks, R. V. Pierre, M. B. O'Sullivan

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

A study was made of the routine electronic measurements of erythrocyte size and hemoglobin concentration in blood samples from 122 patients with decreased transferrin saturation and 66 patients with elevated levels of hemoglobin A₂ or F. The medical histories of these patients were reviewed to identify 52 cases of uncomplicated iron deficiency anemia and 39 cases of uncomplicated thalassemia minor. Four decision functions were compared for separating these two disorders. The functions evaluated were: D.F'. = MCV - [5 x Hb] RBC; ratio MCV/RBC; ratio MCH/RBC; and RBC. The rules performed better in the uncomplicated cases than in the routine laboratory defined cases. Only minor differences in the performances of the various decision functions were observed. None was sufficiently accurate for final diagnosis, but they should have value in screening patients and in determining which additional tests should be considered.

Original language	English (US)
Pages (from-to)	870-877
Number of pages	8
Journal	American journal of clinical pathology
Volume	66
Issue number	5
DOIs	https://doi.org/10.1093/ajcp/66.5.870
State	Published - 1976

ASJC Scopus subject areas

Pathology and Forensic Medicine

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10.1093/ajcp/66.5.870

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abstract = "A study was made of the routine electronic measurements of erythrocyte size and hemoglobin concentration in blood samples from 122 patients with decreased transferrin saturation and 66 patients with elevated levels of hemoglobin A2 or F. The medical histories of these patients were reviewed to identify 52 cases of uncomplicated iron deficiency anemia and 39 cases of uncomplicated thalassemia minor. Four decision functions were compared for separating these two disorders. The functions evaluated were: D.F'. = MCV - [5 x Hb] RBC; ratio MCV/RBC; ratio MCH/RBC; and RBC. The rules performed better in the uncomplicated cases than in the routine laboratory defined cases. Only minor differences in the performances of the various decision functions were observed. None was sufficiently accurate for final diagnosis, but they should have value in screening patients and in determining which additional tests should be considered.",

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Routine erythrocyte measurements in diagnosis of iron deficiency anemia and thalassemia minor

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