Rostral raphe involvement in Lewy body dementia and multiple system atrophy

Eduardo E. Benarroch, A. M. Schmeichel, P. Sandroni, Joseph E Parisi, Phillip Anson Low

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Depression is a feature of both Lewy body disorders and multiple system atrophy (MSA). Since serotonergic neurons of the rostral raphe have been implicated in depression, we sought to determine whether there is a differential involvement of these neurons in cases with clinically diagnosed dementia with Lewy bodies (DLB) or MSA. We studied the brainstem obtained at autopsy from fourteen patients with diagnosis of DLB and pathological limbic or neocortical stage Lewy body disease, 13 patients with clinical and neuropathological diagnosis of MSA, and 12 controls with no history of neurologic disease. The clinical features of these patients were analyzed retrospectively by reviewing their medical records. Serial sections were immunostained for tryptophan hydroxylase (TrOH) and α-synuclein and cell counts were performed in the dorsal raphe (DR), median raphe (MR) and medullary raphe nuclei. There was loss of serotonergic cells in both the DR and MR in DLB compared to control cases: For the DR, the number of cells/section were 53 ± 6 in DLB versus 159 ± 13 (P < 0.001) respectively, and for the MR 70 ± 11 in DLB versus 173 ± 23 (P < 0.001) respectively. In contrast, these cells were relatively preserved in MSA. The caudal raphe groups were affected both in MSA and in DLB. There is a differential involvement of raphe neurons in DLB and MSA. Although loss of rostral raphe neurons may contribute to depression in DLB, this appears to be less likely in MSA. Factors other than the neurochemical phenotype determine neuronal vulnerability in MSA.

Original languageEnglish (US)
Pages (from-to)213-220
Number of pages8
JournalActa Neuropathologica
Volume114
Issue number3
DOIs
StatePublished - Sep 2007

Fingerprint

Multiple System Atrophy
Lewy Body Disease
Depression
Neurons
Cell Count
Synucleins
Tryptophan Hydroxylase
Serotonergic Neurons
Lewy Bodies
Raphe Nuclei
Nervous System Diseases
Brain Stem
Medical Records
Autopsy
Phenotype

Keywords

  • Dorsal raphe
  • Glial cytoplasmic inclusions
  • Median raphe
  • Synucleinopathies

ASJC Scopus subject areas

  • Clinical Neurology
  • Pathology and Forensic Medicine
  • Neuroscience(all)

Cite this

Rostral raphe involvement in Lewy body dementia and multiple system atrophy. / Benarroch, Eduardo E.; Schmeichel, A. M.; Sandroni, P.; Parisi, Joseph E; Low, Phillip Anson.

In: Acta Neuropathologica, Vol. 114, No. 3, 09.2007, p. 213-220.

Research output: Contribution to journalArticle

Benarroch, Eduardo E. ; Schmeichel, A. M. ; Sandroni, P. ; Parisi, Joseph E ; Low, Phillip Anson. / Rostral raphe involvement in Lewy body dementia and multiple system atrophy. In: Acta Neuropathologica. 2007 ; Vol. 114, No. 3. pp. 213-220.
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