Roles of NOTCH1 as a therapeutic target and a biomarker for lung cancer: Controversies and perspectives

Lixia Guo, Ting Zhang, Ying Xiong, Yanan D Yang

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Lung cancer is one of the most common types of human malignancies and the leading cause of cancer-related death. Patients with surgically resectable early stage lung cancer are more likely curable, but currently only a small population of patients can be diagnosed at such a stage, partly due to our incomplete understanding of the biology of lung cancer and the lack of diagnostic and prognostic biomarkers. Recent studies have shown that NOTCH1 is a critical regulator of human carcinogenesis and has been implicated in multiple steps of cancer development and progression. Herein, we review recent findings about the role of NOTCH1 in lung cancer and discuss its potential usefulness as both a therapeutic target and a biomarker for lung cancer.

Original languageEnglish (US)
Article number520590
JournalDisease Markers
Volume2015
DOIs
StatePublished - 2015

ASJC Scopus subject areas

  • Biochemistry, medical
  • Clinical Biochemistry
  • Molecular Biology
  • Genetics

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