Role of vitamin D in cognitive function in chronic kidney disease

Zhen Cheng, Jing Lin, Qi Qian

Research output: Contribution to journalReview article

5 Scopus citations

Abstract

Both vitamin D deficiency and cognitive impairment are common in patients with chronic kidney disease (CKD). Vitamin D exerts neuroprotective and regulatory roles in the central nervous system. Hypovitaminosis D has been associated with muscle weakness and bone loss, cardiovascular diseases (hypertension, diabetes and hyperlipidemia), inflammation, oxidative stress, immune suppression and neurocognitive impairment. The combination of hypovitaminosis D and CKD can be even more debilitating, as cognitive impairment can develop and progress through vitamin D-associated and CKD-dependent/independent processes, leading to significant morbidity and mortality. Although an increasingly recognized comorbidity in CKD, cognitive impairment remains underdiagnosed and often undermanaged. Given the association of cognitive decline and hypovitaminosis D and their deleterious effects in CKD patients, determination of vitamin D status and when appropriate, supplementation, in conjunction with neuropsychological screening, should be considered integral to the clinical care of the CKD population.

Original languageEnglish (US)
Article number291
JournalNutrients
Volume8
Issue number5
DOIs
StatePublished - May 1 2016

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Keywords

  • Chronic kidney disease
  • Cognitive impairment
  • Dialysis
  • Hypovitaminosis D
  • Vitamin D

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

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