Role of tumor-stromal interactions in pancreatic cancer invasion and metastases

Rachel L.O. Olson, Judith V. Forner, Pilar Navarro, Martin E Fernandez-Zapico, Ahmed M. Elamir

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Pancreatic cancer tumor microenvironment (TME), simply defined as the noncancerous desmoplastic reaction, is considered a key player in all aspects of tumor growth, and progression. The dismal prognosis of pancreatic cancer and disappointing clinical trials has drawn our attention to the TME, particularly to the tumor-stromal interactions. While a myriad of molecular, pathological, and clinical features contribute to the lethality of pancreatic cancer, local invasiveness and distant metastases is a hallmark and leading cause of mortality and morbidity in this ominous cancer. Cancer-associated stromal cells including stellate cells have been implicated in epithelial mesenchymal transition (EMT), a process involved in invasion and metastases. In addition, the pre-metastatic niche, immune evasion, and enhancement of angiogenesis have been attributed to these cells. Interactions of the tumor stromal complex operate as a command and logistics center for pancreatic cancer cells, triggering and maintaining invasiveness and metastases. Understanding and modulating these interactions is a promising strategy to tame one of the most aggressive human cancers to date.

Original languageEnglish (US)
Title of host publicationPancreatic Cancer
PublisherSpringer New York
Pages539-552
Number of pages14
ISBN (Electronic)9781493971930
ISBN (Print)9781493971916
DOIs
StatePublished - Apr 11 2018

Keywords

  • Cancer-associated fibroblast
  • Metastasis
  • Pancreatic cancer
  • Pancreatic cancer stellate cells
  • Tumor microenvironment
  • Tumor-cell interaction

ASJC Scopus subject areas

  • Medicine (miscellaneous)

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  • Cite this

    Olson, R. L. O., Forner, J. V., Navarro, P., Fernandez-Zapico, M. E., & Elamir, A. M. (2018). Role of tumor-stromal interactions in pancreatic cancer invasion and metastases. In Pancreatic Cancer (pp. 539-552). Springer New York. https://doi.org/10.1007/978-1-4939-7193-0_89